Evidence map›Paper›PMID 36411713›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2022

Mechanism of chronic stress to promote tumor development and the intervention.

Yi Liu, Yue Zeng, Yizheng Li, Jiawen Ke, Yue Pan, Xiaohan Liu, Yurong Peng, Fang Wu

Open access · greenAbstract read
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Yi LiuDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011. liuyi0308@csu.edu.cn.
Yue ZengDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
Yizheng LiDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
Jiawen KeDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
Yue PanDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
Xiaohan LiuDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
Yurong PengDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
Fang WuDepartment of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011. wufang4461@csu.edu.cn.
Central South University · CN

Funding

the Changsha Science and Technology Planning Project kq1907077the Hunan Provincial Natural Science Foundation for Excellent Young Scholars 2021JJ20088the National Natural Science Foundation 82272806the Science and Research Fund of Beijing Xisike Clinical Oncology Research Foundation Y-HS202102-0130 and Y-BMS2019-100the Talent Program of Chinese Thoracic Oncology Group/Guangdong Provincial Key Laboratory of Lung Cancer Translational Medicine 2017B030314120
6 · The paper itself

Abstract

Chronic stress is a serial of non-specific neuroendocrine reactions in the body when stimulated by stressors for a long time, which has been shown to have a significant effect on tumor development. Chronic stress can activate the hypothalamus-pituitary-adrenal axis and the sense-adrenal myelin system, promote catecholamine and adrenal corticosteroid secretion, regulate the downstream pathways at all levels, and modulate the secretion of immune cells and immune factors, inhibit protective immune response, and induce inflammation, thus promoting tumor cell proliferation and metastasis. Some drugs and psychotherapy can alleviate the patient's stress state, block the nerve signal transmission at all levels of access, regulate the immune system, or can become an effective means to intervene in chronic stress in tumor patients for clinical treatment to provide reference for intervention ideas. However, due to lack of relevant clinical trials, the clinical intervention effect of various drugs and psychotherapy is uncertain and needs more studies to verify the effect.

Indexed as

Graft vs Host DiseaseNeoplasmsHumansHypothalamo-Hypophyseal SystemImmune SystemPituitary-Adrenal Systemchronic stressendocrineimmunityinterventiontumor

Identifiers

PMID36411713
PMCPMC10930318
OpenAlexW4309661086

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.