Evidence map›Paper›PMID 36417254›Full record

ArticleEpidemiologia (Basel, Switzerland)2022

Would New SARS-CoV-2 Variants Change the War against COVID-19?

Elrashdy M Redwan, Fatma Elrashdy, Alaa A A Aljabali, Wagner Baetas-da-Cruz, Debmalya Barh, Adam M Brufsky, Sk Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Kazuo Takayama and 3 more

Abstract read
In one paragraph

Article in Epidemiologia (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elrashdy M RedwanDepartment of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-8246-0075
Fatma ElrashdyDepartment of Endemic Medicine and Hepatogastroenterology, Cairo University, Cairo 12111, Egypt.ORCID 0000-0001-6263-4015
Alaa A A AljabaliDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid 566, Jordan.ORCID 0000-0002-9519-6338
Wagner Baetas-da-CruzTranslational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, RJ, Brazil.ORCID 0000-0001-7847-022X
Debmalya BarhInstitute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur 721172, West Bengal, India.ORCID 0000-0002-2557-7768
Adam M BrufskyUPMC Hillman Cancer Center, Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.ORCID 0000-0001-8080-7960
Sk Sarif HassanDepartment of Mathematics, Pingla Thana Mahavidyalaya, Maligram, Paschim Medinipur 721140, West Bengal, India.ORCID 0000-0003-4331-722X
Kenneth LundstromPanTherapeutics, Rte de Lavaux 49, CH 1095 Lutry, Switzerland.
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.ORCID 0000-0002-9953-3848
Kazuo TakayamaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0002-1132-2457
Murtaza M TambuwalaSchool of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, UK.ORCID 0000-0001-8499-9891
Bruce D UhalDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-5201-432X
Vladimir N UverskyDepartment of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-4037-5857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evolves continually into new highly virulent variants, which might overcome the protection provided by vaccines and may re-expose the population to infections. Mass vaccinations should be continued in combination with more or less mandatory non-pharmaceutical interventions. Therefore, the key questions to be answered are: (i) How to identify the primary and secondary infections of SARS-CoV-2? (ii) Why are neutralizing antibodies not long-lasting in both cases of natural infections and post-vaccinations? (iii) Which are the factors responsible for this decay in neutralizing antibodies? (iv) What strategy could be adapted to develop long-term herd immunity? (v) Is the Spike protein the only vaccine target or is a vaccine cocktail better?

Indexed as

COVID-19immunityinfectionnon-pharmaceutical interventionsSARS-CoV-2sublineagetransmissionvaccinationvariant

Identifiers

PMID36417254
PMCPMC9620871

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.