ArticleScience advances2022
A pleiotropic hypoxia-sensitive
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 25 citations in OpenAlex.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Chronic high-altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular-immune-neuronal network.Neuroprotection (Chichester, England) · 2026Review
- Article
- Current research on the HIF-2α-EPO-Hb axis in hypoxic environments: from molecular mechanisms to clinical.Frontiers in medicine · 2026Review
- Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Lineage-specific regulatory evolution: insights from massively parallel reporter assays.Current opinion in genetics & development · 2025Review
- Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice.Nature communications · 2025Article
- Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan Pigs.Molecular biology and evolution · 2025Article
- Advances in Understanding Adaptive Hemoglobin Concentration at High Altitude.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Comparative transcriptomics of iPSC-derived cardiomyocytes in a high and a low altitude population.bioRxiv : the preprint server for biology · 2025Article
- Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.Cancer discovery · 2025Article
- Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal Cells.Endocrinology · 2025Article
- Transcriptomic analysis of iPSC-derived endothelium reveals adaptations to high altitude hypoxia in energy metabolism and inflammation.PLoS genetics · 2025Article
- A history of multiple Denisovan introgression events in modern humans.Nature genetics · 2024Review
- Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Massively parallel approaches for characterizing noncoding functional variation in human evolution.Current opinion in genetics & development · 2024Review
- Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells.The Journal of cell biology · 2024Article
- FunctionalScience advances · 2024Article
- Hypoxia Inducible Factor pathway proteins in high-altitude mammals.Trends in biochemical sciences · 2024Review
- High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele.Molecular biology and evolution · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Olivia A GrayDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-6585-9049
Jennifer Yoo
Débora R SobreiraDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2232-3922
Jordan JousmaDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-5434-2573
David WitonskyDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Noboru J SakabeDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-1817-6090
Ying-Jie PengInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-8302-5198
Nanduri R PrabhakarInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-4570-1380
Yun FangDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-4597-3095
Marcelo A NobrégaDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2134-9661
Anna Di RienzoDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8982-9098
University of Chicago · US
Funding
RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1MPREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0MMechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI RAMIREZ, JAN M. · 2019 to 2023
$12.7MGenetic adaptations to high altitudeR01HL119577 · NHLBI · UNIVERSITY OF CHICAGO · PI DI RIENZO, ANNA · 2014 to 2023
$4.9MPrecision nanomedicine targeting novel endothelial mechano-sensing mechanismsR35HL161244 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang · 2022 to 2026
$4.0MFunctional analyses of EPAS1 alleles from populations adapted to high altitudeF31HL142146 · NHLBI · UNIVERSITY OF CHICAGO · PI GRAY, OLIVIA ANNE · 2018 to 2020
$111kNHLBI NIH HHS F31 HL142146NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R01 HL119577NHLBI NIH HHS R35 HL161244NHLBI NIH HHS T32 HL007605NIGMS NIH HHS T32 GM007197
Abstract
In Tibetans, noncoding alleles in
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.