Evidence map›Paper›PMID 36419600›Full record

ArticleFish and shellfish immunology reports2022

Device implant based on poly (lactic acid) with vitamin E for vaccine delivery system in Tilapia: Study for biocompatibility and biodegradation.

Gabriel Conde, Mayumi Fernanda Aracati, Letícia Franchin Rodrigues, Susana Luporini de Oliveira, Camila Carlino da Costa, Ives Charlie-Silva, Thalles Fernando Rocha Ruiz, Sebastião Roberto Taboga, Marco Antonio de Andrade Belo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fish and shellfish immunology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gabriel CondeDepartment of Preventive Veterinary Medicine, São Paulo State University (Unesp), Rodovia de Acesso Paulo Donato Castellane s/n, Zona Rural, zipcode 14884-900, Jaboticabal, SP, Brazil.
Mayumi Fernanda AracatiDepartment of Preventive Veterinary Medicine, São Paulo State University (Unesp), Rodovia de Acesso Paulo Donato Castellane s/n, Zona Rural, zipcode 14884-900, Jaboticabal, SP, Brazil.
Letícia Franchin RodriguesDepartment of Preventive Veterinary Medicine, São Paulo State University (Unesp), Rodovia de Acesso Paulo Donato Castellane s/n, Zona Rural, zipcode 14884-900, Jaboticabal, SP, Brazil.
Susana Luporini de OliveiraDepartment of Preventive Veterinary Medicine, São Paulo State University (Unesp), Rodovia de Acesso Paulo Donato Castellane s/n, Zona Rural, zipcode 14884-900, Jaboticabal, SP, Brazil.
Camila Carlino da CostaDepartment of Preventive Veterinary Medicine, São Paulo State University (Unesp), Rodovia de Acesso Paulo Donato Castellane s/n, Zona Rural, zipcode 14884-900, Jaboticabal, SP, Brazil.
Ives Charlie-SilvaDeparment of Pharmacology, Institute of Biomedical Science, University of São Paulo (USP). 2415 Prof. Lineu Prestes Avenue, Cidade Universitária, São Paulo SP, ZipCode:05508-000, Brazil.
Thalles Fernando Rocha RuizDepartment of Biology, São Paulo State University (Unesp), 2265 Cristóvão Colombo, Jardim Nazareth, zipcode 15054-000, São José do Rio Preto, SP, Brazil.
Sebastião Roberto TabogaDepartment of Biology, São Paulo State University (Unesp), 2265 Cristóvão Colombo, Jardim Nazareth, zipcode 15054-000, São José do Rio Preto, SP, Brazil.
Marco Antonio de Andrade BeloDepartment of Preventive Veterinary Medicine, São Paulo State University (Unesp), Rodovia de Acesso Paulo Donato Castellane s/n, Zona Rural, zipcode 14884-900, Jaboticabal, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade Brasil · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of Poly (lactic acid) (PLA) as a slow-release vehicle for vaccines has attracted the attention of researchers, since its insertion improves the uptake of them, and reduces side effects or by stimulating recruited defense cells, assisting immunity without the need for booster vaccine doses. Seeking to develop new strategies for the administration of drugs and vaccines in aquaculture, we evaluated the biocompatibility and biodegradation of polymeric PLA devices and PLA plus vitamin E devices, implanted through subcutaneous (SC) and intraperitoneal (IP) routes in Nile tilapia. To carry out this study, 84 male tilapia (initial 243.82 ± 56.74 g; final 400.71 ± 100.54 g) were randomly distributed in 3 tanks (

Indexed as

BiomaterialsClinical safetyInflammatory responseInnate immunityOreochromis niloticus

Identifiers

PMID36419600
PMCPMC9680062
OpenAlexW4283788585

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.