SynthesisFrontiers in integrative neuroscience2022
Risk of dementia or Parkinson's disease in the presence of Sjögren's syndrome: A systematic review and meta-analysis.
Synthesis in Frontiers in integrative neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Depression mediated sleep disturbances and cognitive decline in Parkinson's disease patient.Frontiers in neuroscience · 2026Article
- Oral health implications in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Concomitant Pathologies and Their Impact on Parkinson Disease: A Narrative Overview of Current Evidence.International journal of molecular sciences · 2025Review
- Increased risk of dementia in patients with primary Sjogren's syndrome: a nationwide population-based cohort study.The Korean journal of internal medicine · 2025Article
- Diversity of central nervous system manifestations in Sjogren's Disease: a case-based review.Rheumatology international · 2025Article
- Sex differences in depression in Parkinson's disease: cognitive dysfunction and female-specific associations.Frontiers in neuroscience · 2025Article
- The Spectrum of Movement Disorders Associated with Systemic Lupus Erythematosus.Current neurology and neuroscience reports · 2024Review
- Sjögren's syndrome and Parkinson's disease: a bidirectional Mendelian randomization study.Frontiers in genetics · 2024Article
- The interaction between the nervous system and the stomatognathic system: from development to diseases.International journal of oral science · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Evidence from observational studies suggests that Sjögren's syndrome (SS) may contribute to an elevated risk of Parkinson's disease (PD) and dementia. However, few studies have been undertaken to summarize and assess the consistency of the data quantitatively. Therefore, we evaluated the risk of dementia and PD in SS patients through a systematic review and meta-analysis approach. Methods: Two reviewers independently conducted a systematic search of PubMed, Embase, and Web of Science databases (updated to February 14, 2022) to identify published literature on the association between SS and dementia or PD. The risk estimates of dementia or PD in patients with SS were pooled using fixed or random-effects models. Results: Of the 631 studies initially searched, 10 were eventually included. Pooled results suggested that the risk of developing dementia significantly increased in patients with SS (HR = 1.24, 95% CI: 1.15-1.33, Conclusion: Our study supports that people with SS are at higher risk of PD and dementia than the general population. Further studies are needed to elucidate the underlying mechanisms and to assess whether interventions for SS have the potential to affect dementia and PD development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.