Evidence map›Paper›PMID 36420261›Full record

ArticleFrontiers in immunology2022

Human papillomavirus infection can alter the level of tumour stemness and T cell infiltration in patients with head and neck squamous cell carcinoma.

Lingzhang Meng, Heming Lu, Yueyong Li, Jingjie Zhao, Siyuan He, Zechen Wang, Jiajia Shen, Huixian Huang, Jinru Xiao, Suren Rao Sooranna and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Cuproptosis-related gene subtypes predict prognosis in patients with head and neck squamous cell carcinoma.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Lingzhang MengInstitute of Cardiovascular Sciences, Guangxi Academy of Medical Sciences, Nanning, China.
Heming LuSecond Division of Department of Radiation Oncology, Guangxi Academy of Medical Sciences, Nanning, China.
Yueyong LiDepartment of Interventive Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Jingjie ZhaoLife Science and Clinical Research Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Siyuan HeCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, China.
Zechen WangCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, China.
Jiajia ShenCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, China.
Huixian HuangSecond Division of Department of Radiation Oncology, Guangxi Academy of Medical Sciences, Nanning, China.
Jinru XiaoGraduate School, Guangxi University of Chinese Medicine, Nanning, China.
Suren Rao SoorannaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, Chelsea & Westminster Hospital, London, United Kingdom.
Jian SongInstitute of Cardiovascular Sciences, Guangxi Academy of Medical Sciences, Nanning, China.
Affiliated Hospital of Youjiang Medical University for Nationalities · CNThe People's Hospital of Guangxi Zhuang Autonomous Region · CNChelsea and Westminster Hospital · GBGuangxi Academy of Sciences · CNGuangxi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) usually has a poor prognosis and is associated with a high mortality rate. Its etiology is mainly the result from long-term exposure to either alcohol, tobacco or human papillomavirus (HPV) infection or a combination of these insults. However, HNSCC patients with HPV have been found to show a survival advantage over those without the virus, but the mechanism that confers this advantage is unclear. Due to the large number of HPV-independent HNSCC cases, there is a possibility that the difference in prognosis between HPV-positive (HPV

Indexed as

Head and Neck NeoplasmsPapillomavirus InfectionsCD8-Positive T-LymphocytesHumansImmune Checkpoint ProteinsPapillomaviridaeSquamous Cell Carcinoma of Head and NeckImmune Checkpoint Proteinshead and neck squamous cell carcinomahuman papillomavirusimmune checkpoint genesprognosis markerssingle cell transcriptomictumour infiltrating immune cellstumour stemness

Identifiers

PMID36420261
PMCPMC9676257
OpenAlexW4308317646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.