Evidence map›Paper›PMID 36420488›Full record

ArticleFish and shellfish immunology reports2021

Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection.

Ning Su, Chong-Bin Hu, Tong Shao, Chun-Yu Jin, Hao Li, Jian-Fei Ji, Lu-Lu Qin, Dong-Dong Fan, Ai-Fu Lin, Li-Xin Xiang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Fish and shellfish immunology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ning SuCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Chong-Bin HuCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Tong ShaoCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Chun-Yu JinCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Hao LiCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Jian-Fei JiCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Lu-Lu QinCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Dong-Dong FanCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Ai-Fu LinCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Li-Xin XiangCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Jian-Zhong ShaoCollege of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, 866 YuHangTang Road, Hangzhou 310058, China.
Zhejiang University · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD40 and CD154 are one of the best-characterized costimulatory molecules essential for adaptive immunity, which extensively involved in T and B cell activation, IgM Ab production, isotype class switching, germinal center formation and affinity maturation. However, the functionality of CD40 and CD154 in IgZ-mediated immunity remains limited. In this study, we explored the regulatory role of Cd40-Cd154 interaction in IgZ-mediated antibacterial immunity in zebrafish. The results showed that the IgZ-mediated antibacterial response can be significantly induced in response to

Indexed as

Antibacterial immunityCD154CD40Costimulatory regulationIgZ

Identifiers

PMID36420488
PMCPMC9680072
OpenAlexW3214533752

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.