Evidence map›Paper›PMID 36421903›Full record

ArticleBrain sciences2022

The Association between High Mobility Group Box 1 and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients.

Yan E, Qiwen Deng, Guomei Shi, Zhongyuan Li, Chengfang Liu, Siyu Wang, Huiwen Lian, Haiming Cao, Xiaohao Zhang, Yingdong Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yan EDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Qiwen DengDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Guomei ShiDepartment of Neurology, Taixing People's Hospital, Taixing 225400, China.
Zhongyuan LiDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Chengfang LiuDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Siyu WangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Huiwen LianDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Haiming CaoDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Xiaohao ZhangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Yingdong ZhangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Pengyu GongDepartment of Neurology, The Affiliated Hospital of Nantong University, Nantong 226000, China.
Teng JiangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Nanjing Medical University · CNNantong University · CNTaixing People's Hospital · CN

Funding

Natural Science Foundation of Jiangsu Province BK20221175
6 · The paper itself

Abstract

Objective: This study aimed to investigate the association between high-mobility-group box 1 (HMGB1) and stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients. Methods: AIS patients were enrolled in two centers. The serum samples were collected within the first 24 h after admission, and HMGB1 levels were measured by enzyme-linked immunosorbent assay. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) of SAP for HMGB1 concentrations. Restricted cubic splines (RCS) were performed to explore the shapes of the association between HMGB1 concentrations and SAP. Results: From January 2022 to May 2022, a total of 420 AIS patients were enrolled. Ninety-six (22.9%) patients develop SAP. The levels of HMGB1 in the SAP group were higher than those in the non-SAP group (p < 0.001). Using the first quartile of HMGB1 group as a reference, patients in the fourth quartile of HMGB1 group had the highest likelihood of experiencing SAP in the unadjusted model (OR = 3.687; 95% CI: 1.851−7.344), age- and sex-adjusted model (OR = 3.511; 95% CI: 1.725−7.147), and multivariable-adjusted model (OR = 2.701; 95% CI: 1.045−6.981). HMGB1 was also independently associated with SAP as a continuous variable in the unadjusted model (OR = 1.132; 95% CI: 1.069−1.199), age- and sex-adjusted model (OR = 1.131; 95% CI: 1.066−1.200), and multivariable-adjusted model (OR = 1.096; 95% CI: 1.011−1.188). RCS showed a linear association between HMGB1 and SAP (p for linear trend = 0.008) Conclusions: HMGB1 might be able to act as a potential biomarker of SAP in AIS patients.

Indexed as

acute ischemic strokebiomarkerhigh-mobility-group box 1restricted cubic splinestroke-associated pneumonia

Identifiers

PMID36421903
PMCPMC9688221
OpenAlexW4309740539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.