Evidence map›Paper›PMID 36422754›Full record

SynthesisBreast cancer research and treatment2023

Circadian rhythm disrupting behaviours and cancer outcomes in breast cancer survivors: a systematic review.

Kelly D'cunha, Yikyung Park, Melinda M Protani, Marina M Reeves

Open access · hybridFull text readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

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  4. Circadian clock and cancer.Military Medical Research · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kelly D'cunhaSchool of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. k.dcunha@uq.edu.au.ORCID http://orcid.org/0000-0003-3552-1714
Yikyung ParkDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6281-489X
Melinda M ProtaniSchool of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-6452-7571
Marina M ReevesSchool of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-3052-2013
The University of Queensland · AUWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCircadian rhythm disruptors (e.g., night-shift work) are risk factors for breast cancer, however studies on their association with prognosis is limited. A small but growing body of research suggests that altered sleep patterns and eating behaviours are potential mechanistic links between circadian rhythm disruptors and breast cancer. We therefore systematically summarised literature examining the influence of circadian rhythm disrupting behaviours on cancer outcomes in women with breast cancer.

methodsA systematic search of five databases from inception to January 2021 was conducted. Original research published in English, assessing the relationship between post-diagnosis sleep patters and eating behaviours, and breast cancer outcomes were considered. Risk of bias was assessed using the Newcastle-Ottawa Assessment Scale for Cohort Studies.

resultsEight studies published original evidence addressing sleep duration and/or quality (k = 7) and, eating time and frequency (k = 1). Longer sleep duration (≥ 9 h versus [referent range] 6-8 h) was consistently associated with increased risk of all outcomes of interest (HR range: 1.37-2.33). There was limited evidence to suggest that measures of better sleep quality are associated with lower risk of all-cause mortality (HR range: 0.29-0.97). Shorter nightly fasting duration (< 13 h versus ≥ 13 h) was associated with higher risk of all breast cancer outcomes (HR range: 1.21-1.36).

conclusionOur review suggests that circadian rhythm disrupting behaviours may influence cancer outcomes in women with breast cancer. While causality remains unclear, to further understand these associations future research directions have been identified. Additional well-designed studies, examining other exposures (e.g., light exposure, temporal eating patterns), biomarkers, and patient-reported outcomes, in diverse populations (e.g., breast cancer subtype-specific, socio-demographic diversity) are warranted.

Indexed as

Breast NeoplasmsCancer SurvivorsCircadian RhythmFemaleHumansRisk FactorsSleepBreast neoplasmsCircadian rhythmFeeding behaviourSleep qualitySurvival

Identifiers

PMID36422754
PMCPMC10036454
OpenAlexW4309924041

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read6
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.