Evidence map›Paper›PMID 36428014›Full record

Trial reportBMJ open2022

Five-year follow-up of patients with knee osteoarthritis not eligible for total knee replacement: results from a randomised trial.

Jesper Bie Larsen, Ewa M Roos, Mogens Laursen, Sinead Holden, Martin Nygaard Johansen, Michael Skovdal Rathleff, Lars Arendt-Nielsen, Sten Rasmussen, Søren T Skou

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01535001 (Structured Non-operative Treatment of Knee Osteoarthritis - a Randomized Controlled Trial of Pain, Physical Function and Quality of Life With 12months Follow-up), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01535001 nacompletednot on this map

Structured Non-operative Treatment of Knee Osteoarthritis - a Randomized Controlled Trial of Pain, Physical Function and Quality of Life With 12months Follow-up

TypeinterventionalSponsorNorthern Orthopaedic Division, DenmarkRan2012 to 2014Enrolled100ConditionsOsteoarthritis of the KneeArmsNeuromuscular training (NEMEX-TJR), Information, Paracetamol, Burana, Pantoprazole
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jesper Bie LarsenMusculoskeletal Health and Implementation, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-3077-7913
Ewa M RoosResearch Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-5425-2199
Mogens LaursenOrthopedic Surgery Research Unit, Aalborg University Hospital, Aalborg, Denmark.
Sinead HoldenMusculoskeletal Health and Implementation, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-7314-2152
Martin Nygaard JohansenUnit of Clinical Biostatistics, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0001-9790-0985
Michael Skovdal RathleffMusculoskeletal Health and Implementation, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Lars Arendt-NielsenTranslational Pain Biomarker, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Sten RasmussenOrthopedic Surgery Research Unit, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0002-8664-352X
Søren T SkouResearch Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark stskou@health.sdu.dk.ORCID 0000-0003-4336-7059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe main objective was to investigate 5-year outcomes in patients with knee osteoarthritis, randomised to one of two non-surgical treatments.

settingTwo outpatient clinics.

participantsAt baseline, 100 patients with radiographic and symptomatic knee osteoarthritis not found eligible for knee replacement (KR) were included. Main exclusion criteria were average score above 75 of the Knee injury and Osteoarthritis Outcome Score (KOOS) subscales pain, symptoms, function of daily living and quality of life; KOOS

interventionsPatients were randomised to supervised non-surgical treatment consisting of patient education, supervised exercise, weight loss, insoles, and pain medication (the MEDIC treatment) or written advice. The 12-week MEDIC treatment included patient education, neuromuscular exercise, insoles and a dietary weight loss programme and/or pain medication if needed and written advice consisted of two leaflets. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome was 5-year mean change for KOOS

resultsThirty-nine (78%) and 36 (72%) from the MEDIC and written advice groups responded at 5 years. There were no between-group differences in KOOS

conclusionsNo statistically significant differences between supervised non-surgical treatment and written advice were demonstrated at 5 years. Most patients experienced clinically important improvements, irrespective of initial treatment strategy or KR. TRIAL REGISTRATION NUMBER: NCT01535001; ClinicalTrials.gov.

Indexed as

Arthroplasty, Replacement, KneeOsteoarthritis, KneeFollow-Up StudiesHumansPainQuality of LifeKneeMusculoskeletal disordersOrthopaedic & trauma surgeryREHABILITATION MEDICINERHEUMATOLOGY

Identifiers

PMID36428014
PMCPMC9703324

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.