Evidence map›Paper›PMID 36428084›Full record

Trial reportOpen heart2022

Prognosis in asymptomatic patients with discordantly graded aortic valve stenosis based on pressure recovery adjusted valve area.

Edda Bahlmann, Eigir Einarsen, Dana Cramariuc, Eva R Pedersen, Anne B Rossebø, Helga Midtbø, Stephan Willems, Eva Gerdts

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Open heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00092677 (A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effects of Ezetimibe + Simvastatin on Clinical Outcomes in Patients With Aortic Stenosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00092677 phase3completednot on this map

A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effects of Ezetimibe + Simvastatin on Clinical Outcomes in Patients With Aortic Stenosis

TypeinterventionalSponsorOrganon and CoRan2001 to 2008Enrolled1,873ConditionsAortic StenosisArmsezetimibe (+) simvastatin, Comparator: Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Edda BahlmannDepartment of Cardiology, Asklepios Clinic St. Georg, Hamburg, Germany doc_edda@hotmail.com.ORCID 0000-0002-4242-0535
Eigir EinarsenDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-6672-3370
Dana CramariucDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Eva R PedersenDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-3063-6010
Anne B RossebøDepartment of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway.
Helga MidtbøDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-3558-9914
Stephan WillemsDepartment of Cardiology, Asklepios Clinic St. Georg, Hamburg, Germany.
Eva GerdtsDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-4109-2311
University of Bergen · NOAsklepios Klinik St. Georg · DEHaukeland University Hospital · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe hypothesised that patients with asymptomatic aortic stenosis (AS) who remain with discordantly graded aortic valve stenosis (DGAS) after adjustment for pressure recovery in the aortic root represents a subgroup of patients with increased cardiovascular risk.

methodsData from 1353 patients with asymptomatic mild-moderate AS and preserved left ventricular ejection fraction enrolled in the Simvastatin and Ezetimibe in AS study was used. DGAS was identified as combined pressure adjusted valve area (energy loss) <1.0 cm² and mean aortic gradient<40 mm Hg (DGAS

resultsDGAS

conclusionsPatients with asymptomatic AS who remain with discordant grading after adjustment for pressure recovery have increased risk for HF and death. TRIAL REGISTRATION NUMBER: NCT00092677.

Indexed as

Aortic Valve StenosisVentricular Function, LeftAortic ValveFemaleHumansMalePrognosisStroke VolumeAortic Valve StenosisEchocardiographyHypertension

Identifiers

PMID36428084
PMCPMC9703352
OpenAlexW4309971509

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.