Evidence map›Paper›PMID 36430716›Full record

ArticleInternational journal of molecular sciences2022

In Vitro Study of the Therapeutic Potential of Brown Crude Fucoidans in Osteoarthritis Treatment.

Carlos Vaamonde-García, Emma Capelo-Mera, Noelia Flórez-Fernández, María Dolores Torres, Beatriz Rivas-Murias, Rosa Mejide-Faílde, Francisco J Blanco, Herminia Domínguez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Carlos Vaamonde-GarcíaGrupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Biología, Facultad de Ciencias, CICA-Centro Interdisciplinar de Química y Biología, INIBIC-Sergas, Universidade da Coruña, Campus da Zapateira, 15011 A Coruña, Spain.ORCID 0000-0001-8658-5502
Emma Capelo-MeraGrupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Biología, Facultad de Ciencias, CICA-Centro Interdisciplinar de Química y Biología, INIBIC-Sergas, Universidade da Coruña, Campus da Zapateira, 15011 A Coruña, Spain.
Noelia Flórez-FernándezGrupo de Biomasa y Desarrollo Sostenible (EQ2), Departamento de Ingeniería Química, Facultad de Ciencias, CINBIO, Universidade de Vigo, 32004 Ourense, Spain.ORCID 0000-0002-2666-2315
María Dolores TorresGrupo de Biomasa y Desarrollo Sostenible (EQ2), Departamento de Ingeniería Química, Facultad de Ciencias, CINBIO, Universidade de Vigo, 32004 Ourense, Spain.ORCID 0000-0001-6811-1290
Beatriz Rivas-MuriasCACTI, Universidade de Vigo, 36310 Vigo, Spain.ORCID 0000-0002-8048-5364
Rosa Mejide-FaíldeGrupo de Terapia Celular y Medicina Regenerativa, Universidade da Coruña, CICA-Centro Interdisciplinar de Química y Biología, Complexo Hospitalario Universitario A Coruña, Campus Oza, 15006 A Coruña, Spain.ORCID 0000-0001-8516-9419
Francisco J BlancoGrupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, CICA-Centro Interdisciplinar de Química y Biología, INIBIC-Sergas, Universidade da Coruña, Campus de Oza, 15006 A Coruña, Spain.ORCID 0000-0001-9821-7635
Herminia DomínguezGrupo de Biomasa y Desarrollo Sostenible (EQ2), Departamento de Ingeniería Química, Facultad de Ciencias, CINBIO, Universidade de Vigo, 32004 Ourense, Spain.ORCID 0000-0002-6475-3242
Universidade da Coruña · ESUniversidade de Vigo · ES

Funding

Instituto de Salud Carlos III CIBERMinistry of Science, Technology, Knowledge and Innovation RYC2018-024454-IXunta de Galicia ED431F 2020/01Xunta de Galicia ED481D-2022-018Xunta de Galicia IN607A 2021/7
6 · The paper itself

Abstract

Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a long time. Brown seaweed crude fucoidans are used for the clinical treatment of several pathologies. In this study, the therapeutical potential of these biocompounds was analyzed in primary chondrocytes and the 260TT human chondrocyte cell line. Crude fucoidan from

Indexed as

OsteoarthritisUndariaAnti-Inflammatory AgentsHumansInterleukin-6PolysaccharidesAnti-Inflammatory AgentsfucoidanInterleukin-6Polysaccharideschondrocytescrude fucoidanshemeoxygenase 1nuclear factor-erythroid 2-related factorosteoarthritisproinflammatory cytokinesreactive oxygen speciessenescence

Identifiers

PMID36430716
PMCPMC9698873
OpenAlexW4309461892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.