Evidence map›Paper›PMID 36442294›Full record

ArticleMedical image analysis2023

Signed graph representation learning for functional-to-structural brain network mapping.

Haoteng Tang, Lei Guo, Xiyao Fu, Yalin Wang, Scott Mackin, Olusola Ajilore, Alex D Leow, Paul M Thompson, Heng Huang, Liang Zhan

Abstract read
In one paragraph

Article in Medical image analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. BPEN: Brain Posterior Evidential Network for trustworthy brain imaging analysis.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
  6. Interpretable Spatio-Temporal Embedding for Brain Structural-Effective Network with Ordinary Differential Equation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  7. Article
  8. Article
  9. Bidirectional Mapping with Contrastive Learning on Multimodal Neuroimaging Data.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haoteng TangUniversity of Pittsburgh, 3700 O'Hara St., Pittsburgh, 15261, PA, USA. Electronic address: haoteng.tang@pitt.edu.
Lei GuoUniversity of Pittsburgh, 3700 O'Hara St., Pittsburgh, 15261, PA, USA.
Xiyao FuUniversity of Pittsburgh, 3700 O'Hara St., Pittsburgh, 15261, PA, USA.
Yalin WangArizona State University, 699 S Mill Ave., Tempe, 85281, AZ, USA.
Scott MackinUniversity of California San Francisco, 505 Parnassus Ave., San Francisco, 94143, CA, USA.
Olusola AjiloreUniversity of Illinois Chicago, 1601 W. Taylor St., Chicago, 60612, IL, USA.
Alex D LeowUniversity of Illinois Chicago, 1601 W. Taylor St., Chicago, 60612, IL, USA.
Paul M ThompsonUniversity of Southern California, 2001 N. Soto St., Los Angeles, 90032, CA, USA.
Heng HuangUniversity of Pittsburgh, 3700 O'Hara St., Pittsburgh, 15261, PA, USA.
Liang ZhanUniversity of Pittsburgh, 3700 O'Hara St., Pittsburgh, 15261, PA, USA. Electronic address: liang.zhan@pitt.edu.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
Connecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regressionRF1MH125928 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEOW, ALEX, WU, YICHAO · 2021 to 2021
$1.3M
NCATS NIH HHS UL1 TR000448NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NEI NIH HHS R01 EY032125NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG071243NIA NIH HHS R21 AG043760NIA NIH HHS U01 AG068057NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB009352NIMH NIH HHS RF1 MH125928NIMH NIH HHS U01 MH093765
6 · The paper itself

Abstract

MRI-derived brain networks have been widely used to understand functional and structural interactions among brain regions, and factors that affect them, such as brain development and diseases. Graph mining on brain networks can facilitate the discovery of novel biomarkers for clinical phenotypes and neurodegenerative diseases. Since brain functional and structural networks describe the brain topology from different perspectives, exploring a representation that combines these cross-modality brain networks has significant clinical implications. Most current studies aim to extract a fused representation by projecting the structural network to the functional counterpart. Since the functional network is dynamic and the structural network is static, mapping a static object to a dynamic object may not be optimal. However, mapping in the opposite direction (i.e., from functional to structural networks) are suffered from the challenges introduced by negative links within signed graphs. Here, we propose a novel graph learning framework, named as Deep Signed Brain Graph Mining or DSBGM, with a signed graph encoder that, from an opposite perspective, learns the cross-modality representations by projecting the functional network to the structural counterpart. We validate our framework on clinical phenotype and neurodegenerative disease prediction tasks using two independent, publicly available datasets (HCP and OASIS). Our experimental results clearly demonstrate the advantages of our model compared to several state-of-the-art methods.

Indexed as

Neurodegenerative DiseasesBrainBrain MappingHumansLearningNeuroimagingFunctional networkMultimodalPredictionReconstructionSigned graph learningStructural network

Identifiers

PMID36442294
PMCPMC9904311

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.