Evidence map›Paper›PMID 36445556›Full record

ReviewNeuroscience bulletin2023

Triggering of Major Brain Disorders by Protons and ATP: The Role of ASICs and P2X Receptors.

Andrii Cherninskyi, Maksim Storozhuk, Oleksandr Maximyuk, Vyacheslav Kulyk, Oleg Krishtal

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. 4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors.International journal of molecular sciences · 2024
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrii Cherninskyi *Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, 01024, Ukraine. andrii.cherninskyi@biph.kiev.ua.ORCID http://orcid.org/0000-0003-4058-1834
Maksim Storozhuk *Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, 01024, Ukraine.ORCID http://orcid.org/0000-0001-5525-4137
Oleksandr Maximyuk *Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, 01024, Ukraine.ORCID http://orcid.org/0000-0003-3288-4974
Vyacheslav KulykBogomoletz Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, 01024, Ukraine.ORCID http://orcid.org/0000-0003-2300-2431
Oleg KrishtalBogomoletz Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, 01024, Ukraine.ORCID http://orcid.org/0000-0003-3342-9930
National Academy of Sciences of Ukraine · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells. Less known is that this molecule has a variety of important signaling functions: it activates a variety of specific metabotropic (P2Y) and ionotropic (P2X) receptors in neuronal and non-neuronal cell membranes. So, a wide variety of signaling functions well fits the ubiquitous presence of ATP in the tissues. Even more ubiquitous are protons. Apart from the unspecific interaction of protons with any protein, many physiological processes are affected by protons acting on specific ionotropic receptors-acid-sensing ion channels (ASICs). Both protons (acidification) and ATP are locally elevated in various pathological states. Using these fundamentally important molecules as agonists, ASICs and P2X receptors signal a variety of major brain pathologies. Here we briefly outline the physiological roles of ASICs and P2X receptors, focusing on the brain pathologies involving these receptors.

Indexed as

Acid Sensing Ion ChannelsAdenosine TriphosphateBrain DiseasesProtonsReceptors, Purinergic P2XAcid Sensing Ion Channel BlockersAlzheimer DiseaseAmyotrophic Lateral SclerosisAnimalsChronic PainCOVID-19EpilepsyHumansHuntington DiseaseIschemic StrokeMental DisordersAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAdenosine TriphosphateProtonsReceptors, Purinergic P2XASICsChronic painEpilepsyNeurodegenerativeP2X receptorsPsychiatric diseasesStroke

Identifiers

PMID36445556
PMCPMC9707125
OpenAlexW4310217070

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.