Evidence map›Paper›PMID 36445674›Full record

ArticleThe international journal of cardiovascular imaging2022

Vessel and sex differences in pericoronary adipose tissue attenuation obtained with coronary CT in individuals without coronary atherosclerosis.

Sophie E van Rosendael, Jurrien H Kuneman, Inge J van den Hoogen, Pieter H Kitslaar, Alexander R van Rosendael, Pieter van der Bijl, Johan H C Reiber, Nina Ajmone Marsan, J Wouter Jukema, Juhani Knuuti and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The Role of Cardiac Computed Tomography Angiography in Risk Stratification for Coronary Artery Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sophie E van RosendaelDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Jurrien H KunemanDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Inge J van den HoogenDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Pieter H KitslaarMedis Medical Imaging Systems, Leiden, The Netherlands.
Alexander R van RosendaelDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Pieter van der BijlDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Johan H C ReiberDivision of Image Processing, Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
Nina Ajmone MarsanDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Juhani KnuutiTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA, Leiden, The Netherlands. j.j.bax@lumc.nl.
Leiden University · NLUniversity of Turku · FICentre for Medical Systems Biology · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pericoronary adipose tissue (PCAT) attenuation, derived from coronary computed tomography angiography (CCTA), is associated with coronary artery inflammation. Values for PCAT attenuation in men and women without atherosclerosis on CCTA are lacking. The aim of the current study was to assess the mean PCAT attenuation in individuals without coronary artery atherosclerosis on CCTA. Data on PCAT attenuation in men and women without coronary artery atherosclerosis on CCTA were included in this retrospective analysis. The PCAT attenuation was analyzed from the proximal part of the right coronary artery (RCA), the left anterior descending artery (LAD), and the left circumflex artery (LCx). For patient level analyses the mean PCAT attenuation was defined as the mean of the three coronary arteries. In 109 individuals (mean age 45 ± 13 years; 44% men), 320 coronary arteries were analyzed. The mean PCAT attenuation of the overall population was - 64.4 ± 8.0 HU. The mean PCAT attenuation was significantly lower in the LAD compared with the LCx and RCA (- 67.8 ± 7.8 HU vs - 62.6 ± 6.8 HU vs - 63.6 ± 7.9 HU, respectively, p < 0.001). In addition, the mean PCAT attenuation was significantly higher in men vs. women in all three coronary arteries (LAD: - 65.7 ± 7.6 HU vs - 69.4 ± 7.6 HU, p = 0.014; LCx: - 60.6 ± 7.4 HU vs - 64.3 ± 5.9 HU, p = 0.008; RCA: -61.7 ± 7.9 HU vs - 65.0 ± 7.7 HU, p = 0.029, respectively). The current study provides mean PCAT attenuation values, derived from individuals without CAD. Moreover, the mean PCAT attenuation is lower in women vs. men. Furthermore, the mean PCAT attenuation is significantly lower in the LAD vs LCx and RCA.

Indexed as

AtherosclerosisCoronary Artery DiseaseAdipose TissueAdultFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesSex CharacteristicsTomography, X-Ray ComputedCoronary artery diseaseCoronary computed tomography angiographyPericoronary adipose tissue attenuationPerivascular inflammation

Identifiers

PMID36445674
PMCPMC9708810
OpenAlexW4293173562

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.