Evidence map›Paper›PMID 36446603›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2022

Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways.

Rong-Yu Liu, Yili Zhang, Paul Smolen, Leonard J Cleary, John H Byrne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Right Time for a Synapse to Change: Windows and Mechanisms of Multiday Training Trials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rong-Yu LiuDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.ORCID 0000-0002-5593-2601
Yili ZhangDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Paul SmolenDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Leonard J ClearyDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
John H ByrneDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

Funding

NEURAL CONTROL OF BEHAVIORR01NS019895 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H · 1985 to 2022
$8.3M
Modeling the Molecular Networks that Underlie the Formation and Consolidation of MemoryR01NS102490 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI John H Byrne · 2018 to 2026
$3.6M
Analysis of the Neural Control of BehaviorR37NS019895 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI John H Byrne · 2023 to 2026
$2.6M
NINDS NIH HHS R01 NS019895NINDS NIH HHS R01 NS102490NINDS NIH HHS R37 NS019895
6 · The paper itself

Abstract

Empirical and computational methods were combined to examine whether individual or dual-drug treatments can restore the deficit in long-term synaptic facilitation (LTF) of the

Indexed as

Coffin-Lowry SyndromeCyclic AMP-Dependent Protein KinasesNeuronal Plasticityp38 Mitogen-Activated Protein KinasesHumansMitogen-Activated Protein KinasesSerotoninCyclic AMP-Dependent Protein KinasesMitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesSerotonin

Identifiers

PMID36446603
PMCPMC9749851

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.