ReviewNature reviews. Neuroscience2023
The Genetically Informed Neurobiology of Addiction (GINA) model.
Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis.Translational psychiatry · 2025Pooled it
- Genetic susceptibility to caffeine intake and metabolism: a systematic review.Journal of translational medicine · 2024Pooled it
- The resting-state brain activity signatures for addictive disorders.Med (New York, N.Y.) · 2024Pooled it
- Classification of Alcohol Use Disorder With Explainable AI.Alcohol, clinical & experimental research · 2026Article
- The brain age gap as a predictor of alcohol initiation in adolescence.Developmental cognitive neuroscience · 2026Article
- Adapter protein 2-modulatedActa pharmacologica Sinica · 2026Article
- Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study.General psychiatry · 2026Article
- Brain Structure and Substance Use: Disentangling Risk, Exposure, and Drug-Specific Effects.medRxiv : the preprint server for health sciences · 2026Article
- The Brain Age Gap as a Predictor of Alcohol Initiation in Adolescence.bioRxiv : the preprint server for biology · 2026Article
- Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology.medRxiv : the preprint server for health sciences · 2026Article
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- Comorbidity of internet gaming disorder and anxiety in first-year Chinese university students: the mediating role of behavioral inhibition and activation systems.BMC psychiatry · 2025Article
- Youth Correlates of Genetic Liability to Substance Use Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Genetic influences for distinct impulsivity domains are differentially associated with early substance use initiation: Results from the ABCD Study.Psychological medicine · 2025Article
- The Roots of Problematic Polydrug Use in Emotional Problems and Suicide Behavior: A Cross-Sectional Study.Brain sciences · 2025Article
- Decoding Encoded Cravings: Epigenetic Drivers of Addiction.Brain sciences · 2025Review
- Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing.Addiction biology · 2025Article
- Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder.Nature. Mental health · 2025Article
- Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.JAMA network open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Addictions are heritable and unfold dynamically across the lifespan. One prominent neurobiological theory proposes that substance-induced changes in neural circuitry promote the progression of addiction. Genome-wide association studies have begun to characterize the polygenic architecture undergirding addiction liability and revealed that genetic loci associated with risk can be divided into those associated with a general broad-spectrum liability to addiction and those associated with drug-specific addiction risk. In this Perspective, we integrate these genomic findings with our current understanding of the neurobiology of addiction to propose a new Genetically Informed Neurobiology of Addiction (GINA) model.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.