SynthesisCommunications biology2022
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium.Clinical epigenetics · 2025Pooled it
- A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.Communications biology · 2022Pooled it
- Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Review
- Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.medRxiv : the preprint server for health sciences · 2026Article
- Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.Current nutrition reports · 2026Review
- Prenatal cell-free DNA methylome detects association with autism and maternal obesity.Communications biology · 2026Article
- The role of placental DNA methylation in the pathogenesis of chronic intervillositis of unknown etiology.Clinical epigenetics · 2025Article
- Placental DNA methylation key topics: sex- and cell-type specificity, mediation, multi-omics, and biomarker discovery.Epigenomics · 2025Review
- Maternal obesity and ancestry distance in influencing birth outcomes.International journal of obesity (2005) · 2025Observational
- Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.Nature communications · 2025Article
- Genetics of glucose homeostasis in pregnancy and postpartum.Diabetologia · 2024Article
- Maternal obesity and placental function: impaired maternal-fetal axis.Archives of gynecology and obstetrics · 2024Review
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells.Epigenetics communications · 2024Article
- Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice.Nutrients · 2023Article
- Imprinted genes and the manipulation of parenting in mammals.Nature reviews. Genetics · 2023Review
- Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 20 institutions in 8 countries.
Nora Fernandez-Jimenez *Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute, Leioa, Basque Country, Spain.ORCID 0000-0001-6307-0880
Ruby Fore *Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Ariadna Cilleros-Portet *Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute, Leioa, Basque Country, Spain.
Johanna LepeuleUniversity Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, Grenoble, France.ORCID 0000-0001-8907-197X
Patrice PerronCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Tuomas KvistDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Fu-Ying TianGangarosa Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
Corina LesseurDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6744-6750
Alexandra M BinderCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Manuel LozanoEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Jordi Martorell-MarugánDepartment of Statistics and Operations Research, University of Granada, Granada, Spain.ORCID 0000-0002-5186-0735
Yuk J LokeMurdoch Children's Research Institute, Parkville, VIC, Australia.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9605-6337
Yihui ZhuDepartment of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California, Davis, CA, USA.ORCID 0000-0002-5405-9994
Anne ForhanUniversité de Paris, Centre for Research in Epidemiology and Statistics (CRESS), INSERM, INRAE, Paris, France.
Sara SammallahtiDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC, Rotterdam, The Netherlands.
Todd M EversonGangarosa Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.ORCID 0000-0003-2732-4550
Jia ChenDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Karin B MichelsDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Thalia BelmonteHealth Research Institute of Asturias, ISPA and Biomedical Research and Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cadiz, Spain.ORCID 0000-0003-1241-6073
Pedro Carmona-SáezDepartment of Statistics and Operations Research, University of Granada, Granada, Spain.ORCID 0000-0002-6173-7255
Jane HallidayMurdoch Children's Research Institute, Parkville, VIC, Australia.
M Daniele FallinWendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Janine M LaSalleDepartment of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California, Davis, CA, USA.ORCID 0000-0002-3480-2031
Jorg TostLaboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob, Evry, France.ORCID 0000-0002-2683-0817
Darina CzamaraMax-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.ORCID 0000-0001-7381-904X
Mariana F FernándezUniversity of Granada, Center for Biomedical Research (CIBM), Granada, Spain.ORCID 0000-0001-6417-8914
Antonio Gómez-MartínInstituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.ORCID 0000-0001-6537-1468
Jeffrey M CraigMurdoch Children's Research Institute, Parkville, VIC, Australia.
Beatriz Gonzalez-AlzagaInstituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Rebecca J SchmidtDepartment of Public Health Sciences and the MIND Institute, University of California Davis School of Medicine, Davis, CA, USA.ORCID 0000-0003-1582-2747
John F DouDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Evelyne MuggliMurdoch Children's Research Institute, Parkville, VIC, Australia.ORCID 0000-0002-8102-9811
Marina LacasañaInstituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.ORCID 0000-0003-0825-9124
Martine VrijheidCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.ORCID 0000-0002-7090-1758
Carmen J MarsitGangarosa Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.ORCID 0000-0003-4566-150X
Margaret R KaragasDepartment of Biochemistry and Functional Genomics, Universite de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0002-6398-7362
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Luigi BouchardDepartment of Biochemistry and Functional Genomics, Universite de Sherbrooke, Sherbrooke, QC, Canada.
Barbara HeudeUniversité de Paris, Centre for Research in Epidemiology and Statistics (CRESS), INSERM, INRAE, Paris, France.ORCID 0000-0002-1565-1629
Loreto Santa-MarinaCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Mariona BustamanteCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.ORCID 0000-0003-0127-2860
Marie-France HivertDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0001-7752-2585
Jose Ramon BilbaoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute, Leioa, Basque Country, Spain. joseramon.bilbao@ehu.eus.ORCID 0000-0002-3176-501X
Emory University · USInstituto de Investigación Biosanitaria de Granada · ESThe University of Melbourne · AUUniversidad de Granada · ESUniversity of California, Davis · USUniversity of the Basque Country · ESHarvard University · USIcahn School of Medicine at Mount Sinai · USInserm · FRUniversitat Pompeu Fabra · ESUniversité de Sherbrooke · CAUniversity of Helsinki · FIUniversity of Michigan · USBasque Government · ESBiomedical Research and Innovation Institute of Cadiz · ESCentre Hospitalier Universitaire de Sherbrooke · CACentre National de la Recherche Scientifique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRDeakin University · AUErasmus MC · NL
Funding
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MPCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)R01ES029213 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Janine M LaSalle, Pamela J Lein · 2018 to 2026
$6.5MFolic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1MBUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESR24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany D. Chambers Butcher, Rebecca Jean Schmidt · 2017 to 2026
$2.3MBUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLESU24ES028533 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAMBERS BUTCHER, BRITTANY D., SCHMIDT, REBECCA JEAN · 2023 to 2025
$1.2MNIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R01 ES029213NIEHS NIH HHS R24 ES028533NIEHS NIH HHS U24 ES028533
Abstract
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings.
Indexed as
DNA MethylationPlacentaBody Mass IndexChildChild HealthFemaleHumansInfant, NewbornMothersPregnancy
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What Socratic holds
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LicenceCC BY
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.