Evidence map›Paper›PMID 36449618›Full record

ArticleScience advances2022

Decreasing

Connor M Kean, Christopher J Tracy, Apratim Mitra, Beenish Rahat, Matthew T Van Winkle, Claudia M Gebert, Jacob A Noeker, Anne L Calof, Arthur D Lander, Judith A Kassis and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Clinical,medRxiv : the preprint server for health sciences · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Cohesin regulation and roles in chromosome structure and function.Current opinion in genetics & development · 2024
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Connor M KeanDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0132-1722
Christopher J TracyDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4532-3327
Apratim MitraDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3279-0054
Beenish RahatDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Matthew T Van WinkleDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0638-2113
Claudia M GebertDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Jacob A NoekerDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4344-3114
Anne L CalofDepartment of Anatomy and Neurobiology, University of California School of Medicine, Irvine, CA, USA.ORCID 0000-0003-3676-2499
Arthur D LanderDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-4380-5525
Judith A KassisDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9268-3213
Karl PfeiferDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0254-682X
National Institutes of Health · USUniversity of California, Irvine · US

Funding

Regulated expression and developmental functions of the H19 long noncoding RNAZIAHD001804 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PFEIFER, KARL ERIC · 2009 to 2025
$20.2M
Control Of Gene Expression During DevelopmentZIAHD005003 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KASSIS, JUDITH ANN · 2009 to 2023
$16.4M
Investigating the multifactorial origins of congenital heart diseaseR01HL138659 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CALOF, ANNE LEIGHTON, LANDER, ARTHUR D · 2017 to 2020
$2.1M
Intramural NIH HHS ZIA HD001804Intramural NIH HHS ZIA HD005003NHLBI NIH HHS R01 HL138659
6 · The paper itself

Abstract

Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for

Indexed as

BrainTranscriptomeAnimalsCell Cycle ProteinsFemaleHeterozygoteHumansMammalsMiceMutationPhenotypePregnancyProteinsCell Cycle ProteinsNIPBL protein, humanProteinsWAPL protein, mouse

Identifiers

PMID36449618
PMCPMC9710879
OpenAlexW4310437437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.