Evidence map›Paper›PMID 36450128›Full record

ArticleCanadian journal of physiology and pharmacology2023

The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.

Hannah M Costello, Alexandria Juffre, Kit-Yan Cheng, Phillip Bratanatawira, G Ryan Crislip, Adrian Zietara, Denisha R Spires, Alexander Staruschenko, Lauren G Douma, Michelle L Gumz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of physiology and pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recent advances in understanding the kidney circadian clock mechanism.American journal of physiology. Renal physiology · 2024
    Review
  5. Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hannah M CostelloDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.
Alexandria JuffreDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.
Kit-Yan ChengDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.
Phillip BratanatawiraDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA.
G Ryan CrislipDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.
Adrian ZietaraDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-7465-060X
Denisha R SpiresDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Alexander StaruschenkoDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33602, USA.ORCID 0000-0002-5190-8356
Lauren G DoumaDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.
Michelle L GumzDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-9655-3798
University of Florida · USMedical College of Wisconsin · USUniversity of South Florida · US

Funding

Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
Modulation of the renal aldosterone endothelin feedback system by the clock protein PER1R56DK128271 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L, WINGO, CHARLES S · 2021 to 2021
$100k
Transport and metabolism in the kidneyI01BX004024 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI STARUSCHENKO, ALEXANDER · 2019 to 2025
–
BLRD VA I01 BX004024NHLBI NIH HHS R35 HL135749NIDDK NIH HHS R01 DK109570NIDDK NIH HHS R56 DK128271
6 · The paper itself

Abstract

Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chronic kidney disease. Previously, our lab has shown that the circadian clock gene PER1 regulates ET-1 levels in mice. However, the regulation of ET-1 by PER1 has never been investigated in rats. Therefore, we used a novel model where knockout of

Indexed as

Circadian ClocksHypertensionAnimalsBlood PressureEndothelin-1EndothelinsKidneyMicePeriod Circadian ProteinsRatsRats, Inbred DahlTranscription FactorsEndothelin-1EndothelinsPer1 protein, mousePer1 protein, ratPeriod Circadian ProteinsTranscription Factorsadrenal glandsendothelin-1ET-1kidneyPeriod1salt-sensitive hypertension

Identifiers

PMID36450128
PMCPMC9992312
OpenAlexW4310571583

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.