Evidence map›Paper›PMID 36450448›Full record

ArticleLife science alliance2023

Revisiting degron motifs in human AURKA required for its targeting by APC/C

Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N Okoye, H Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ahmed AbdelbakiDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Camilla AscanelliDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6266-2822
Cynthia N OkoyeDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0406-3733
H Begum AkmanDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4646-4225
Giacomo JansonDepartment of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Mingwei MinDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9050-5330
Chiara MarcozziDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0038-5556
Anja HagtingDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Rhys GrantDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Maria De LucaDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Italia Anna AsteritiInstitute of Molecular Biology and Pathology, National Research Council of Italy, c/o Sapienza University of Rome, Rome, Italy.
Giulia GuarguagliniInstitute of Molecular Biology and Pathology, National Research Council of Italy, c/o Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-7541-8183
Alessandro PaiardiniDepartment of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-9078-7545
Catherine LindonDepartment of Pharmacology, University of Cambridge, Cambridge, UK acl34@cam.ac.uk.ORCID 0000-0003-3554-2574
University of Cambridge · GBInstitute of Molecular Biology and Pathology · ITSapienza University of Rome · IT

Funding

Biotechnology and Biological Sciences Research Council BB/R004137/1Cancer Research UK C3/A10239
6 · The paper itself

Abstract

Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critically dependent on destruction mediated by the anaphase-promoting complex (APC/C

Indexed as

Aurora Kinase ABiological AssayCdh1 ProteinsCell NucleusHumansAURKA protein, humanAurora Kinase ACdh1 ProteinsFZR1 protein, human

Identifiers

PMID36450448
PMCPMC9713472
OpenAlexW4310438133

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.