ArticleHeliyon2022
Benzo(a)pyrene induced adverse pregnancy outcomes by affecting the expression of IL-18 and IL-1RN in placenta.
Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Inflammatory cytokines can destroy the immune balance and lead to adverse pregnancy outcomes. Benzo (a) pyrene (BaP) may induce premature delivery through leading inflammatory reaction. We screened out inflammatory factors related to adverse pregnancy outcomes through bioinformatics analysis. Then we verified the correlation between adverse pregnancy outcomes caused by BaP and abnormal expression of those inflammatory factors. Main methods: The Gene Expression Omnibus (GEO) database was used to analyze by R to screen the inflammatory genes related to adverse pregnancy outcomes. Based on the established BaP exposure animal model, the expression of key cytokines in placenta was detected by immunohistochemistry. Key findings: According to the data analysis of GEO database, the expression of Significance: BaP may induce the inflammatory reaction to cause adverse pregnancy outcome by regulating the expression of IL18, IL18BP, IL18R and IL1RN. Our findings provide experimental basis for the prevention of adverse pregnancy outcome caused by BaP.
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