Evidence map›Paper›PMID 36453021›Full record

ArticleEpigenomics2022

Stable methylation loci are associated with systolic blood pressure in a Croatian island population.

Alexander C Sprague, Liang Niu, Roman Jandarov, Xiang Zhang, Ge Zhang, Aimin Chen, Jelena Šarac, Miran Čoklo, Sasa Missoni, Pavao Rudan and 2 more

Open access · greenAbstract read
In one paragraph

Article in Epigenomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Alexander C SpragueDivision of Epidemiology, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-0880-6298
Liang NiuDivision of Biostatistics & Bioinformatics, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0002-2473-9745
Roman JandarovDivision of Biostatistics & Bioinformatics, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Xiang ZhangDivision of Environmental Genetics & Molecular Toxicology, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Ge ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jelena ŠaracInstitute for Anthropological Research, Zagreb, Croatia.
Miran ČokloInstitute for Anthropological Research, Zagreb, Croatia.
Sasa MissoniInstitute for Anthropological Research, Zagreb, Croatia.
Pavao RudanAnthropological Center & Scientific Council for Anthropological Research, Croatian Academy of Arts & Sciences, Zagreb, Croatia.
Scott M LangevinDivision of Epidemiology, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0001-7031-1216
Ranjan DekaDivision of Epidemiology, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
University of Cincinnati Medical Center · USInstitute for Anthropological Research · HRCincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USUniversity of Pennsylvania · US

Funding

Genetics of Metabolic Syndrome in an Island PopulationR01DK069845 · NIDDK · UNIVERSITY OF CINCINNATI · PI DEKA, RANJAN · 2006 to 2009
$2.1M
Integrated GWAS and EWAS of Cardiometabolic Traits in an Island PopulationR56HL128493 · NHLBI · UNIVERSITY OF CINCINNATI · PI DEKA, RANJAN · 2016 to 2016
$678k
NHLBI NIH HHS R56 HL128493NIDDK NIH HHS R01 DK069845
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiovascular DiseasesEpigenesis, GeneticAdultBlood PressureCpG IslandsCroatiaDNA MethylationGenome-Wide Association StudyHumans850Kbloodcardiometabolicepigeneticsepigenome-wideepigenomicsEWASpressureSBPsystolic

Identifiers

PMID36453021
PMCPMC9816922
OpenAlexW4310568595

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.