Evidence map›Paper›PMID 36454460›Full record

ArticleAdvances in experimental medicine and biology2023

Genome Editing and Heart Failure.

Daniele Masarone, Martina Caiazza, Federica Amodio, Enrico Melillo, Roberta Pacileo, Giuseppe Limongelli, Giuseppe Pacileo

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniele MasaroneHeart Failure Unit, Department of Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy. danielemasarone@ospedalideicolli.it.
Martina CaiazzaInherited and Rare Cardiovascular Diseases Unit, Department of Traslational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Federica AmodioInherited and Rare Cardiovascular Diseases Unit, Department of Traslational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Enrico MelilloHeart Failure Unit, Department of Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy.
Roberta PacileoHeart Failure Unit, Department of Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy.
Giuseppe LimongelliInherited and Rare Cardiovascular Diseases Unit, Department of Traslational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Giuseppe PacileoHeart Failure Unit, Department of Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy.
Ospedale Monaldi · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure is a leading and growing cause of morbidity and mortality worldwide and clinically is defined by the presence of typical symptoms and signs due structural or functional cardiac abnormalities. In addition to family history of heart failure, genetic predisposition to cardiomyopathies and exposure to cardiotoxic agents, risk factors for heart failure with reduced ejection fraction are the same as for chronic coronary syndrome. Genome editing technologies can provide the tools to correct genetic defects responsible for various diseases, including cardiomyopathies. These technologies aim to reverse specific mutations. The same methods can also be applied to modulate and improve heart function. This chapter will briefly explain the pathophysiological and genetic aspects of heart failure and then discuss the clinical applications of genome editing in patients with heart failure.

Indexed as

Gene EditingHeart FailureHeartHumansRisk FactorsSyndromeBeneficial therapeutic effectDisease modelsGenome editingHeart failure

Identifiers

PMID36454460
OpenAlexW4310500234

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.