Evidence map›Paper›PMID 36456624›Full record

ArticleScientific reports2022

Relationship among surface electric double layer of cardiomyocyte membrane and toxicology of digoxin and opening of ion channels.

Ying Zhou, Yanfei Hao, Pei Sun, Ming Chen, Ting Zhang, Hong Wu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying ZhouThe Sixth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, 100142, China. yzhou_309@sina.com.
Yanfei HaoThe Eighth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, 100091, China.
Pei SunThe Eighth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, 100091, China.
Ming ChenThe Medical Security Center, Chinese People's Liberation Army General Hospital, Beijing, 100039, China.
Ting ZhangThe Eighth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, 100091, China.
Hong WuThe Medical Security Center, Chinese People's Liberation Army General Hospital, Beijing, 100039, China.
Chinese People's Liberation Army · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We applied a new idea that the potential effect can change the ion adsorption structure on the cell surface to explore the mechanism of digoxin poisoning and the regulation of ion channels. The effects of digoxin on the electrophoretic mobility and behaviors (non-contraction or contraction or autorhythmicity) of cardiomyocytes were observed by single-cell electrophoresis technique (imitate the opening method of in vivo channel) and the method of decomposing surface potential components on the cells. As well as affect the association with electrical activity. The results suggested that the increase of cardiomyocytes transmembrane potential and the Na

Indexed as

DigoxinMyocytes, CardiacCell MembraneIon ChannelsMembranesDigoxinIon Channels

Identifiers

PMID36456624
PMCPMC9715572
OpenAlexW4310704942

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.