Evidence map›Paper›PMID 36458737›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

3D Bioelectronics with a Remodellable Matrix for Long-Term Tissue Integration and Recording.

Alexander J Boys, Alejandro Carnicer-Lombarte, Amparo Güemes-Gonzalez, Douglas C van Niekerk, Sam Hilton, Damiano G Barone, Christopher M Proctor, Róisín M Owens, George G Malliaras

Open access · hybridAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. The Future of Biohybrid Regenerative Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  10. Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics.Cyborg and bionic systems (Washington, D.C.) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Alexander J BoysDepartment of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Dr, Cambridge, CB3 0AS, UK.ORCID https://orcid.org/0000-0002-6488-7005
Alejandro Carnicer-LombarteDepartment of Engineering, Electrical Engineering Division, University of Cambridge, 9 JJ Thomson Ave, Cambridge, CB3 0FA, UK.ORCID https://orcid.org/0000-0002-5650-4692
Amparo Güemes-GonzalezDepartment of Engineering, Electrical Engineering Division, University of Cambridge, 9 JJ Thomson Ave, Cambridge, CB3 0FA, UK.ORCID https://orcid.org/0000-0002-4206-6812
Douglas C van NiekerkDepartment of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Dr, Cambridge, CB3 0AS, UK.
Sam HiltonDepartment of Engineering, Electrical Engineering Division, University of Cambridge, 9 JJ Thomson Ave, Cambridge, CB3 0FA, UK.
Damiano G BaroneDepartment of Clinical Neurosciences, University of Cambridge, University Neurology Unit, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID https://orcid.org/0000-0002-0091-385X
Christopher M ProctorDepartment of Engineering, Electrical Engineering Division, University of Cambridge, 9 JJ Thomson Ave, Cambridge, CB3 0FA, UK.
Róisín M OwensDepartment of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Dr, Cambridge, CB3 0AS, UK.ORCID https://orcid.org/0000-0001-7856-2108
George G MalliarasDepartment of Engineering, Electrical Engineering Division, University of Cambridge, 9 JJ Thomson Ave, Cambridge, CB3 0FA, UK.ORCID https://orcid.org/0000-0002-4582-8501
University of Cambridge · GB

Funding

Air Force Office of Scientific Research FA8655-20-1-7021Biotechnology and Biological Sciences Research Council BB/T009314/1ECH2020 Future and Emerging Technologies 732032ECH2020 Future and Emerging Technologies 964677Human Frontier Science Program LT000034/2020-CNational Institute for Health Research CL-2019-14-004Wellcome Trust
6 · The paper itself

Abstract

Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long-term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates a foreign body response, which can limit long-term recording and stimulation efficacy. Techniques from regenerative medicine have shown a high propensity for promoting integration of implants with surrounding tissue, but these implants lack the capabilities for the sophisticated recording and actuation afforded by electronics. Combining these two fields can achieve the best of both worlds. Here, the construction of a hybrid implant system for creating long-term interfaces with tissue is shown. Implants are created by combining a microelectrode array with a bioresorbable and remodellable gel. These implants are shown to produce a minimal foreign body response when placed into musculature, allowing one to record long-term electromyographic signals with high spatial resolution. This device platform drives the possibility for a new generation of implantable electronics for long-term interfacing.

Indexed as

ElectronicsForeign BodiesHumansMicroelectrodesProstheses and ImplantsRegenerative Medicinebioelectronicselectromyographyforeign body responsesregenerative medicines

Identifiers

PMID36458737
PMCPMC11475589
OpenAlexW4310599162

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.