ArticleScience immunology2022
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells.
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In one paragraph
Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 67 citations in OpenAlex.
- Beyond the genetic code: orchestrating epigenetic and immune landscapes with multivalent mRNA-exosome vaccines.Precision clinical medicine · 2026Review
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- An intramuscular prime-intranasal boost strategy for mRNA-LNP vaccine induces mucosal immune response against SARS-CoV-2 in murine model.Journal of translational medicine · 2026Article
- mRNA vaccine development for tuberculosis: antigen design, immune mechanisms, and translational challenges.Archives of microbiology · 2026Review
- mRNA vaccine development for tuberculosis: antigen design, immune mechanisms, and translational challenges.Archives of microbiology · 2026Review
- Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.The Journal of clinical investigation · 2026Article
- Characteristics and therapeutic resistance mechanisms of the prostate cancer immune microenvironment: a comprehensive analysis from bench to clinic.Frontiers in pharmacology · 2026Review
- Lipid nanoparticle-based mRNA platforms for mucosal HIV vaccines: formulation advances, immune mechanisms, and translational pathways.Archives of microbiology · 2025Review
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- RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges.Immunologic research · 2025Review
- Chimeric hemagglutinin-based universal influenza mRNA vaccine induces protective immunity and bone marrow plasma cells in rhesus macaques.Cell reports. Medicine · 2025Article
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- Airway-applied mRNA vaccine needs tailored sequence design and high standard purification that removes devastating dsRNA contaminant.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- CD4Immunology and cell biology · 2025Review
- IL-12 mRNA-LNP promotes dermal resident memory CD4NPJ vaccines · 2025Article
- Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy.Signal transduction and targeted therapy · 2025Article
- Neoantigen-based mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model.Cancer immunology, immunotherapy : CII · 2025Article
- Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity.ACS nano · 2025Article
- Inverted HA-EV immunization elicits stalk-specific influenza immunity and cross-protection in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA.Nature biomedical engineering · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Marco KünzliCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7699-779X
Stephen D O'FlanaganCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9286-1208
Madeleine LaRueCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Poulami TalukderTiba Biotech LLC, Cambridge, MA, USA.
Thamotharampillai DileepanCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2810-6996
J Michael StolleyCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4321-6413
Andrew G SoerensCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7291-8433
Clare F QuarnstromCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Sathi WijeyesingheCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-8819-2654
Yanqi YeEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Justine S McPartlanTiba Biotech LLC, Cambridge, MA, USA.
Jason S MitchellCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4669-9481
Christian W MandlTiba Biotech LLC, Cambridge, MA, USA.
Richard VileDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Marc K JenkinsCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8009-7655
Rafi AhmedEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-9591-2621
Vaiva VezysCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2520-809X
Jasdave S ChahalTiba Biotech LLC, Cambridge, MA, USA.ORCID 0000-0003-3052-0501
David MasopustCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9440-3884
University of Minnesota Medical Center · US490 BioTech (United States) · USEmory University · USMayo Clinic in Arizona · US
Funding
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4MMucosal T Cell Memory to PathogensR01AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI MASOPUST, DAVID · 2010 to 2023
$5.8MMucosal T cell memory to pathogensR37AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2024 to 2026
$1.7MRe-purposing Oncolytic Virotherapy to Re-invigorate CAR T Cell Therapy for Solid Tumors.R01CA269384 · NCI · MAYO CLINIC ROCHESTER · PI Richard G. Vile · 2023 to 2026
$1.4MNCI NIH HHS R01 CA269384NIAID NIH HHS 75N93019C00051NIAID NIH HHS R01 AI084913NIAID NIH HHS R37 AI084913
Abstract
Respiratory tract resident memory T cells (T
Indexed as
CD4-Positive T-LymphocytesVaccinationAnimalsAntibodies, NeutralizingCD8-Positive T-LymphocytesMicemRNA VaccinesRNA, MessengerAntibodies, NeutralizingmRNA VaccinesRNA, Messenger
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.