Evidence map›Paper›PMID 36463192›Full record

ReviewCardiovascular diabetology2022

Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention.

Xiao-Dong Zhou, Jingjing Cai, Giovanni Targher, Christopher D Byrne, Michael D Shapiro, Ki-Chul Sung, Virend K Somers, C Anwar A Chahal, Jacob George, Li-Li Chen and 3 more

Abstract readReview
In one paragraph

Review in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. [Construction norms for the tiered diagnosis and treatment and standardized management center of metabolic-associated fatty liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Guideline
  2. Pooled it
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiao-Dong ZhouDepartment of Cardiovascular Medicine, the Heart Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jingjing CaiDepartment of Cardiology, the Third Xiangya Hospital, Central South University, Changsha, China.
Giovanni TargherDepartment of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Verona, Verona, Italy.
Christopher D ByrneSouthampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
Michael D ShapiroCenter for Prevention of Cardiovascular Disease, Section On Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Ki-Chul SungDepartment of Internal Medicine, Division of Cardiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Virend K SomersDepartment of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, USA.
C Anwar A ChahalDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Jacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia.
Li-Li ChenMAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yong ZhouClinical Research Institute, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ming-Hua ZhengMAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. zhengmh@wmu.edu.cn.
CHESS-MAFLD consortium

Funding

Disease Mechanisms in Sleep ApneaR01HL065176 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 1999 to 2021
$5.8M
Disrupted Sleep in Somali Americans – Implications for Hypertension RiskR01HL160619 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 2022 to 2025
$3.1M
NHLBI NIH HHS R01 HL065176NHLBI NIH HHS R01 HL160619NIH HHS HL65176
6 · The paper itself

Abstract

The newly proposed term "metabolic dysfunction-associated fatty liver disease" (MAFLD) is replacing the old term "non-alcoholic fatty liver disease" (NAFLD) in many global regions, because it better reflects the pathophysiology and cardiometabolic implications of this common liver disease. The proposed change in terminology from NAFLD to MAFLD is not simply a single-letter change in an acronym, since MAFLD is defined by a set of specific and positive diagnostic criteria. In particular, the MAFLD definition specifically incorporates within the classification recognized cardiovascular risk factors. Although convincing evidence supports a significant association between both NAFLD and MAFLD, with increased risk of CVD morbidity and mortality, neither NAFLD nor MAFLD have received sufficient attention from the Cardiology community. In fact, there is a paucity of scientific guidelines focusing on this common and burdensome liver disease from cardiovascular professional societies. This Perspective article discusses the rationale and clinical relevance for Cardiologists of the newly proposed MAFLD definition.

Indexed as

CardiologyCardiovascular DiseasesNon-alcoholic Fatty Liver DiseaseHeart Disease Risk FactorsHumansRisk FactorsCardiovascular diseaseMetabolic dysfunction-associated fatty liver disease (MAFLD)Non-alcoholic fatty liver disease (NAFLD)PharmacotherapiesRisk factors

Identifiers

PMID36463192
PMCPMC9719631

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.