Evidence map›Paper›PMID 36463521›Full record

ArticleInorganic chemistry2022

Divalent 2-(4-Hydroxyphenyl)benzothiazole Bifunctional Chelators for

Karna Terpstra, Yujue Wang, Truc T Huynh, Nilantha Bandara, Hong-Jun Cho, Buck E Rogers, Liviu M Mirica

Open access · greenAbstract read
In one paragraph

Article in Inorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Design of bifunctional pyridinophane ligands as MnInorganic chemistry frontiers · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Karna TerpstraDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.
Yujue WangDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.
Truc T HuynhDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63108, United States.
Nilantha BandaraDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63108, United States.
Hong-Jun ChoDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.
Buck E RogersDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63108, United States.ORCID 0000-0001-8189-1797
Liviu M MiricaDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.ORCID 0000-0003-0584-9508
University of Illinois Urbana-Champaign · USWashington University in St. Louis · US

Funding

NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASESR01GM114588 · NIGMS · WASHINGTON UNIVERSITY · PI MIRICA, LIVIU M. · 2015 to 2019
$1.4M
NIGMS NIH HHS R01 GM114588
6 · The paper itself

Abstract

Herein, we report a new series of divalent 2-(4-hydroxyphenyl)benzothiazole bifunctional chelators (BFCs) with high affinity for amyloid β aggregates and favorable lipophilicity for blood-brain barrier penetration. The addition of an alkyl carboxylate ester pendant arm offers high binding affinity toward Cu(II). The novel BFCs form stable

Indexed as

Alzheimer DiseaseChelating AgentsPositron-Emission TomographyAmyloid beta-PeptidesAnimalsBenzothiazolesMicePlaque, AmyloidTissue Distribution2-(4-hydroxyphenyl)benzothiazoleAmyloid beta-PeptidesBenzothiazolesChelating Agents

Identifiers

PMID36463521
PMCPMC9887732
OpenAlexW4310668713

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.