Evidence map›Paper›PMID 36465130›Full record

ArticleiScience2022

Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility.

Rachel M Woodhouse, Natalya Frolows, Guoqiang Wang, Azelle Hawdon, Edmund Heng Kin Wong, Linda C Dansereau, Yingying Su, Liam D Adair, Elizabeth J New, Ashleigh M Philp and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Rachel M WoodhouseThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Natalya FrolowsThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Guoqiang WangDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Azelle HawdonThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Edmund Heng Kin WongThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Linda C DansereauGarvan Institute of Medical Research, Sydney, NSW 2010, Australia.
Yingying SuSydney Microscopy and Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia.
Liam D AdairThe University of Sydney, School of Chemistry, Sydney, NSW 2006, Australia.
Elizabeth J NewThe University of Sydney, School of Chemistry, Sydney, NSW 2006, Australia.
Ashleigh M PhilpSt Vincent's Clinical School, UNSW Medicine, University of NSW, Sydney, NSW 2010, Australia.
Wei Kang TanThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
Andrew PhilpCentre for Healthy Ageing, Centenary Institute, Missenden Road, Sydney, NSW 2050, Australia.
Alyson AsheThe University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
The University of Sydney · AUAustralian National University · AUGarvan Institute of Medical Research · AURutgers, The State University of New Jersey · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the

Indexed as

biochemistryBiological sciencescell biologymolecular biology

Identifiers

PMID36465130
PMCPMC9709242
OpenAlexW4308977245

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.