Evidence map›Paper›PMID 36479477›Full record

ReviewJournal of preventive medicine and hygiene2022

Modern vision of the Mediterranean diet.

Aysha Karim Kiani, Maria Chiara Medori, Gabriele Bonetti, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Amerigo Iaconelli, Liborio Stuppia, Stephen Thaddeus Connelly, Karen L Herbst and 1 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of preventive medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07007169 (Mediterranean Diet and Inequality in Early Breast Cancer), which is not on this map. Cited by 78 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07007169 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Mediterranean Diet and Inequality in Early Breast Cancer: A Multicenter Randomized Clinical Trial

TypeinterventionalSponsorEsbjerg Hospital - University Hospital of Southern DenmarkRan2025 to 2036Enrolled105ConditionsEarly Breast CancerArmsThe goal is daily consumption of a minimum of 30 grams of dietary fiber and weekly consumption of a minimum of 30 different plant foods, minimizing the amount of ultra-processed food., Standard Diet
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aysha Karim KianiMAGI EUREGIO, Bolzano, Italy.
Maria Chiara MedoriMAGI'S LAB, Rovereto (TN), Italy.
Gabriele BonettiMAGI'S LAB, Rovereto (TN), Italy.
Barbara AquilantiUOSD Medicina Bariatrica, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Valeria VellutiUOSD Medicina Bariatrica, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Giuseppina MateraUOSD Medicina Bariatrica, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Amerigo IaconelliUOSD Medicina Bariatrica, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Liborio StuppiaDepartment of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University, Chieti, Italy.
Stephen Thaddeus ConnellySan Francisco Veterans Affairs Health Care System, Department of Oral & Maxillofacial Surgery, University of California, San Francisco, CA, USA.
Karen L HerbstTotal Lipedema Care, Beverly Hills California and Tucson Arizona, USA.
Matteo BertelliMAGI EUREGIO, Bolzano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mediterranean diet is the most well-known and researched dietary pattern worldwide. It is characterized by the consumption of a wide variety of foods, such as extra-virgin olive oil (EVOO), legumes, cereals, nuts, fruits, vegetables, dairy products, fish, and wine. Many of these foods provide several phytonutrients, among which polyphenols and vitamins play an important role. Data from several studies have strongly established that nutrition is a key factor in promoting a healthy lifestyle and preventing many chronic diseases. In particular, a large number of studies have established the protective effects of the Mediterranean diet against several chronic diseases, among which are diabetes, cardiovascular diseases, cancer, aging disorders, and against overall mortality. Animal and human translational studies have revealed the biological mechanisms regulating the beneficial effects of the traditional Mediterranean diet. Indeed, several studies demonstrated that this nutritional pattern has lipid-lowering, anticancer, antimicrobial, and anti-oxidative effects. Moreover, the Mediterranean diet is considered environmentally sustainable. In this review, we describe the composition of the Mediterranean diet, assess its beneficial effects, and analyze their epigenomic, genomic, metagenomic, and transcriptomic aspects. In the future it will be important to continue exploring the molecular mechanisms through which the Mediterranean diet exerts its protective effects and to standardize its components and serving sizes to understand more precisely its effects on human health.

Indexed as

Diet, MediterraneanHumansAnticancer effectsAntidiabetic effectsAntimicrobial effectsMediterranean dietModification of hormone release

Identifiers

PMID36479477
PMCPMC9710405

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.