Evidence map›Paper›PMID 36479563›Full record

ArticleFrontiers in cardiovascular medicine2022

Prognostic value of a left atrioventricular coupling index in pre- and post-menopausal women from the Multi-Ethnic Study of Atherosclerosis.

Théo Pezel, Erin D Michos, Vinithra Varadarajan, Mahsima Shabani, Bharath Ambale Venkatesh, Dhananjay Vaidya, Yoko Kato, Henrique Doria De Vasconcellos, Susan R Heckbert, Colin O Wu and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005487 (Multi-Ethnic Study of Atherosclerosis), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005487 active not recruitingnot on this map

Multi-Ethnic Study of Atherosclerosis (MESA)

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1999 to 2030Enrolled6,418ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Cardiovascular magnetic resonance-derived left atrioventricular coupling index and major adverse cardiac events in patients following acute myocardial infarction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. CMR-based cardiac phenotyping in different forms of heart failure.The international journal of cardiovascular imaging · 2024
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Théo PezelDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Erin D MichosDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Vinithra VaradarajanDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Mahsima ShabaniDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Bharath Ambale VenkateshDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Dhananjay VaidyaDepartment of Medicine Division of General Medicine, The Johns Hopkins University, Baltimore, MD, United States.
Yoko KatoDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Henrique Doria De VasconcellosDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, United States.
Colin O WuDivision of Intramural Research, National Heart Lung and Blood Institute, Bethesda, MD, United States.
Wendy S PostDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
David A BluemkeDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Matthew A AllisonDivision of Preventive Medicine, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, United States.
Patrick HenryUniversité de Paris Cité, Service de Cardiologie, Hôpital Universitaire Lariboisière - APHP, Paris, France.
Joao A C LimaDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Johns Hopkins University · USHôpital Lariboisière · FRNational Heart Lung and Blood Institute · USUniversity of California, San Diego · USUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sex hormones associated with both the left atrial (LA) and left ventricular (LV) structures in women, but the association of menopause status with left atrioventricular coupling is not established. Aim: To assess the prognostic value of a left atrioventricular coupling index (LACI) in peri-menopausal women without a history of cardiovascular disease (CVD). Materials and methods: In all women participating in MESA study with baseline cardiovascular MRI, the LACI was measured as the ratio of the LA end-diastolic volume to the LV end-diastolic volume. Cox models were used to assess the association between the LACI and the outcomes of atrial fibrillation (AF), heart failure (HF), coronary heart disease (CHD) death, and hard CVD. Results: Among the 2,087 women participants (61 ± 10 years), 485 cardiovascular events occurred (mean follow-up: 13.2 ± 3.3 years). A higher LACI was independently associated with AF (HR 1.70; 95%CI [1.51-1.90]), HF (HR 1.62; [1.33-1.97]), CHD death (HR 1.36; [1.10-1.68]), and hard CVD (HR 1.30; [1.13-1.51], all Conclusion: In a multi-ethnic population of pre- and post-menopausal women, the LACI is an independent predictor of HF, AF, CHD death, and hard CVD. Clinical trial registration: [https://clinicaltrials.gov/], identifier [NCT00005487].

Indexed as

cardiovascular events (CVE)cardiovascular magnetic resonanaceleft atrioventricular couplingmenopauseMulti-Ethnic Study of Atherosclerosis (MESA)prognosissex hormones (SH)

Identifiers

PMID36479563
PMCPMC9719991
OpenAlexW4309738277

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.