Evidence map›Paper›PMID 36480775›Full record

ArticleJCO clinical cancer informatics2022

Development of Machine Learning Algorithms Incorporating Electronic Health Record Data, Patient-Reported Outcomes, or Both to Predict Mortality for Outpatients With Cancer.

Ravi B Parikh, Jill S Hasler, Yichen Zhang, Manqing Liu, Corey Chivers, William Ferrell, Peter E Gabriel, Caryn Lerman, Justin E Bekelman, Jinbo Chen

Abstract read
In one paragraph

Article in JCO clinical cancer informatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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  7. Review
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  9. Article
  10. An overview and a roadmap for artificial intelligence in hematology and oncology.Journal of cancer research and clinical oncology · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ravi B ParikhDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-2692-6306
Jill S HaslerDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0003-3094-9455
Yichen ZhangLeonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-5546-4708
Manqing LiuDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Corey ChiversPenn Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-7290-2183
William FerrellDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-9966-1973
Peter E GabrielPenn Center for Cancer Care Innovation, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-3772-9669
Caryn LermanUSC Norris Comprehensive Cancer Center, Los Angeles, CA.
Justin E BekelmanDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-7624-0188
Jinbo ChenDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0003-3174-2552

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Data and Information Integration for Risk Prediction in the Era of Big DataR01CA236468 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHEN, JINBO · 2019 to 2024
$2.2M
Statistical Methods for Analyzing Electronic Health Record DataR01HL138306 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHEN, JINBO · 2018 to 2020
$1.2M
Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced CancerK08CA263541 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PARIKH, RAVI BHARAT · 2021 to 2025
$1.2M
Predictive Modeling with High-Dimensional lncomplete DataR01GM140463 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, ZIJIAN · 2020 to 2022
$560k
NCATS NIH HHS UL1 TR001878NCI NIH HHS K08 CA263541NCI NIH HHS R01 CA236468NHLBI NIH HHS R01 HL138306NIGMS NIH HHS R01 GM140463
6 · The paper itself

Abstract

purposeMachine learning (ML) algorithms that incorporate routinely collected patient-reported outcomes (PROs) alongside electronic health record (EHR) variables may improve prediction of short-term mortality and facilitate earlier supportive and palliative care for patients with cancer.

methodsWe trained and validated two-phase ML algorithms that incorporated standard PRO assessments alongside approximately 200 routinely collected EHR variables, among patients with medical oncology encounters at a tertiary academic oncology and a community oncology practice.

resultsAmong 12,350 patients, 5,870 (47.5%) completed PRO assessments. Compared with EHR- and PRO-only algorithms, the EHR + PRO model improved predictive performance in both tertiary oncology (EHR + PRO

conclusionRoutinely collected PROs contain added prognostic information not captured by an EHR-based ML mortality risk algorithm. Augmenting an EHR-based algorithm with PROs resulted in a more accurate and clinically relevant model, which can facilitate earlier and targeted supportive care for patients with cancer.

Indexed as

Electronic Health RecordsNeoplasmsHumansMachine LearningPalliative CarePatient Reported Outcome Measures

Identifiers

PMID36480775
PMCPMC10166444

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.