Evidence map›Paper›PMID 36481972›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Neuroimaging characteristics may aid in diagnosis, subtyping, and prognosis in autoimmune encephalitis.

James Broadley, Robb Wesselingh, Paul Beech, Udaya Seneviratne, Chris Kyndt, Katherine Buzzard, Cassie Nesbitt, Wendyl D'Souza, Amy Brodtmann, Richard Macdonell and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

James BroadleyDepartment of Neuroscience, Central Clinical School, Monash University, Level 6 Alfred Center, 55 Commercial Road, Melbourne, Australia.
Robb WesselinghDepartment of Neuroscience, Central Clinical School, Monash University, Level 6 Alfred Center, 55 Commercial Road, Melbourne, Australia.
Paul BeechDepartment of Radiology, Alfred Health, Melbourne, Australia.
Udaya SeneviratneDepartment of Neuroscience, Central Clinical School, Monash University, Level 6 Alfred Center, 55 Commercial Road, Melbourne, Australia.
Chris KyndtDepartment of Neurosciences, Eastern Health, Melbourne, Australia.
Katherine BuzzardDepartment of Neurosciences, Eastern Health, Melbourne, Australia.
Cassie NesbittDepartment of Neuroscience, Barwon Health, Geelong, Australia.
Wendyl D'SouzaDepartment of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Australia.
Amy BrodtmannDepartment of Neurosciences, Eastern Health, Melbourne, Australia.
Richard MacdonellDepartment of Neurology, Austin Health, Melbourne, Australia.
Tomas KalincikDepartment of Medicine, The University of Melbourne, Melbourne, Australia.
Terence J O'BrienDepartment of Neuroscience, Central Clinical School, Monash University, Level 6 Alfred Center, 55 Commercial Road, Melbourne, Australia.
Helmut ButzkuevenDepartment of Neuroscience, Central Clinical School, Monash University, Level 6 Alfred Center, 55 Commercial Road, Melbourne, Australia.
Mastura MonifDepartment of Neuroscience, Central Clinical School, Monash University, Level 6 Alfred Center, 55 Commercial Road, Melbourne, Australia. Mastura.Monif@monash.edu.au.ORCID http://orcid.org/0000-0001-6404-9768
Australian Autoimmune Encephalitis Consortium
The University of Melbourne · AUAlfred Health · AUBarwon Health · AUMonash Health · AUAustin Health · AUEastern Health · AUMonash Alfred Psychiatry Research centre · AU

Funding

National Health and Medical Research Council APP 1201062
6 · The paper itself

Abstract

objectiveTo examine the utility of neuroimaging characteristics as biomarkers of prognosis in seropositive autoimmune encephalitis (AE).

methodsIn this multi-center study, we retrospectively analyzed 66 cases of seropositive AE. The MRI and PET imaging was assessed by independent visual inspection. Whole brain and regional volumes were imputed by IcoMetrix, an automated volumetric assessment package. The modified Rankin Scale (mRS) was utilized to assess the patients' follow-up disability. Other outcomes were mortality, first line treatment failure, medial temporal lobe (MTL) atrophy, and clinical relapse. Univariate and multivariable regression analysis was performed.

resultsAbnormalities on MRI were detected in 35.1% of patients, while PET was abnormal in 46.4%. Initial median whole brain and hippocampal volumes were below the 5th and 20th percentile respectively compared to an age-matched healthy database. After a median follow-up of 715 days, 85.2% had good functional outcome (mRS ≤ 2). Nine patients developed MTL atrophy during follow-up. On multivariable analysis, inflammatory MTL changes were associated with development of MTL atrophy (HR 19.6, p = 0.007) and initial hippocampal volume had an inverse relationship with mortality (HR 0.04, p = 0.011). Patients who developed MTL atrophy had a reduced chance of good final mRS (HR 0.16, p = 0.015).

conclusionsNeuroimaging on initial hospital admission may be provide important diagnostic and prognostic information. This study demonstrates that structural and inflammatory changes of the MTL may have importance in clinical and radiological prognosis in seropositive AE.

Indexed as

Autoimmune Diseases of the Nervous SystemNeuroimagingAtrophyEncephalitisHashimoto DiseaseHumansMagnetic Resonance ImagingPrognosisRetrospective StudiesAtrophyAutoimmune encephalitisMRIPETPrognosis

Identifiers

PMID36481972
OpenAlexW4310958824

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.