Evidence map›Paper›PMID 36482969›Full record

ArticlebioRxiv : the preprint server for biology2024

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants.

Kristin Metzdorf, Henning Jacobsen, Yeonsu Kim, Luiz Gustavo Teixeira Alves, Upasana Kulkarni, Kathrin Eschke, M Zeeshan Chaudhry, Markus Hoffmann, Federico Bertoglio, Maximilian Ruschig and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Kristin MetzdorfDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Henning JacobsenDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Yeonsu KimDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Luiz Gustavo Teixeira AlvesBerlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Upasana KulkarniDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Kathrin EschkeDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
M Zeeshan ChaudhryDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Markus HoffmannInfection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.
Federico BertoglioDepartment of Medical Biotechnology, Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany.
Maximilian RuschigDepartment of Medical Biotechnology, Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany.
Michael HustDepartment of Medical Biotechnology, Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany.
Maja Cokarić BrdovčakCenter for Proteomics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.
Jelena MaterljanCenter for Proteomics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.
Marko ŠustićCenter for Proteomics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.
Astrid KrmpotićDepartment of Histology and Embryology, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.
Stipan JonjićCenter for Proteomics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia.
Marek WideraInstitute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0001-5417-9307
Sandra CiesekInstitute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-1802-7565
Stefan PöhlmannInfection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.
Markus LandthalerBerlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Luka Čičin-ŠainDepartment of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID 0000-0003-3978-778X
Helmholtz Centre for Infection Research · DEUniversity of Rijeka · HRTechnische Universität Braunschweig · DEGerman Primate Center · DEGoethe University Frankfurt · DEMax Delbrück Center · DEGerman Center for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have led to vaccine fatigue. Hence, vaccines that would provide lasting protection against COVID-19 are needed, but are still unavailable. Cytomegaloviruses (CMV) elicit lasting and uniquely strong immune responses. Used as vaccine vectors, they may be attractive tools that obviate the need for boosters. Therefore, we tested the murine CMV (MCMV) as a vaccine vector against COVID-19 in relevant preclinical models of immunization and challenge. We have previously developed a recombinant murine CMV (MCMV) vaccine vector expressing the spike protein of the ancestral SARS-CoV-2 (MCMV

Indexed as

COVID-19in vivolong-lasting protectionMCMVmouseSARS-CoV-2single-dosevaccination

Identifiers

PMID36482969
PMCPMC9727759
OpenAlexW4310121852

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.