Evidence map›Paper›PMID 36483038›Full record

ArticleFrontiers in oncology2022

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K

Brigitte Pelzmann, Ahmed Hatab, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Dieter Platzer, Klaus Zorn-Pauly, Stephan W Jahn and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Ion channel mutations and cancer.Biochemistry and biophysics reports · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Brigitte PelzmannGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Ahmed HatabGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Susanne ScheruebelGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Sonja LangthalerInstitute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Graz, Austria.
Theresa RienmuellerInstitute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Graz, Austria.
Armin SokolowskiDepartment of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Astrid GorischekGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Dieter PlatzerGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Klaus Zorn-PaulyGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Stephan W JahnDiagnostic & Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Thomas BauernhoferDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Wolfgang SchreibmayerGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Medical University of Graz · ATGraz University of Technology · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of somatic mutations. We focused our research on 15 missense mutations within the region between TM1 and TM2, comprising the pore helix and ion selectivity signature. Expression was measured by confocal laser scan microscopy of eGFP tagged GIRK1 subunits, expressed with and without GIRK4 in oocytes of

Indexed as

confocal laser scanning microcopyGIRK1ion channels and cancersomatic mutation analysistwo electrode voltage clampXenopus laevis (X. laevis)

Identifiers

PMID36483038
PMCPMC9724741
OpenAlexW4307869251

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.