Evidence map›Paper›PMID 36499024›Full record

ReviewInternational journal of molecular sciences2022

An Overview of the Molecular Cues and Their Intracellular Signaling Shared by Cancer and the Nervous System: From Neurotransmitters to Synaptic Proteins, Anatomy of an All-Inclusive Cooperation.

Marco Arese, Federico Bussolino, Margherita Pergolizzi, Laura Bizzozero

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marco AreseDepartment of Oncology, University of Torino, 10060 Candiolo, TO, Italy.ORCID 0000-0002-7384-9406
Federico BussolinoDepartment of Oncology, University of Torino, 10060 Candiolo, TO, Italy.ORCID 0000-0002-5348-1341
Margherita PergolizziDepartment of Oncology, University of Torino, 10060 Candiolo, TO, Italy.
Laura BizzozeroDepartment of Oncology, University of Torino, 10060 Candiolo, TO, Italy.

Funding

Fondazione Umberto Veronesi Young Investigator Grant 2014 (to M. A.)Italian Association for Cancer Research # 22910, #12182 # 18652Italian Association for Cancer Research AIRC IG grants #11503 #15238
6 · The paper itself

Abstract

We propose an overview of the molecular cues and their intracellular signaling involved in the crosstalk between cancer and the nervous system. While "cancer neuroscience" as a field is still in its infancy, the relation between cancer and the nervous system has been known for a long time, and a huge body of experimental data provides evidence that tumor-nervous system connections are widespread. They encompass different mechanisms at different tumor progression steps, are multifaceted, and display some intriguing analogies with the nervous system's physiological processes. Overall, we can say that many of the paradigmatic "hallmarks of cancer" depicted by Weinberg and Hanahan are affected by the nervous system in a variety of manners.

Indexed as

NeoplasmsSignal TransductionHumansNervous SystemNeurotransmitter AgentsNeurotransmitter Agentsautocrine/paracrine interactionshallmarks of cancersignal transductiontumor–nervous system molecular crosstalk

Identifiers

PMID36499024
PMCPMC9739679

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.