Evidence map›Paper›PMID 36499545›Full record

ArticleInternational journal of molecular sciences2022

Anti-Thymocyte Globulin (ATG)-Free Nonmyeloablative Haploidentical PBSCT Plus Post-Transplantation Cyclophosphamide Is a Safe and Efficient Treatment Approach for Pediatric Acquired Aplastic Anemia.

Rong-Long Chen, Peng Peng Ip, Jy-Juinn Shaw, Yun-Hsin Wang, Li-Hua Fan, Yi-Ling Shen, Nithila A Joseph, Tsen-Erh Chen, Liuh-Yow Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Rong-Long ChenDepartment of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-sen Cancer Center, Taipei 11259, Taiwan.ORCID 0000-0003-0290-9886
Peng Peng IpInstitute of Molecular Biology, Academia Sinica, Taipei 115024, Taiwan.
Jy-Juinn ShawSchool of Law, National Yang Ming Chiao Tung University, Hsinchu City 30093, Taiwan.
Yun-Hsin WangDepartment of Chemistry, Tamkang University, Tamsui, New Taipei City 251301, Taiwan.
Li-Hua FanDepartment of Pharmacy, Koo Foundation Sun Yat-sen Cancer Center, Taipei 11259, Taiwan.
Yi-Ling ShenInstitute of Molecular Biology, Academia Sinica, Taipei 115024, Taiwan.
Nithila A JosephInstitute of Molecular Biology, Academia Sinica, Taipei 115024, Taiwan.
Tsen-Erh ChenInstitute of Molecular Biology, Academia Sinica, Taipei 115024, Taiwan.
Liuh-Yow ChenInstitute of Molecular Biology, Academia Sinica, Taipei 115024, Taiwan.ORCID 0000-0002-9857-068X
Institute of Molecular Biology, Academia Sinica · TWKoo Foundation Sun Yat-Sen Cancer Center · TWNational Yang Ming Chiao Tung University · TWTamkang University · TW

Funding

Family Association for Children with Serious Illness, Taiwan FACSI 211001
6 · The paper itself

Abstract

Most cases of acquired aplastic anemia (AA) arise from autoimmune destruction of hematopoietic stem and progenitor cells. Human leukocyte antigen (HLA)-haploidentical nonmyeloablative hematopoietic stem cell transplantation (HSCT) plus post-transplantation cyclophosphamide (PTCy) is increasingly applied to salvage AA using bone marrow as graft and anti-thymocyte globulin (ATG) in conditioning. Herein, we characterize a cohort of twelve AA patients clinically and molecularly, six who possessed other immunological disorders (including two also carrying germline

Indexed as

Anemia, AplasticGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAntilymphocyte SerumChildCyclophosphamideHLA AntigensHumansRetrospective StudiesTransplantation ConditioningAntilymphocyte SerumCyclophosphamideHLA Antigensanti-thymocyte globulinnonmyeloablative haploidentical peripheral blood stem cell transplantationpost-transplantation cyclophosphamideSAMD9L variantsevere aplastic anemia

Identifiers

PMID36499545
PMCPMC9739033
OpenAlexW4311517677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.