Evidence map›Paper›PMID 36500573›Full record

ArticleMolecules (Basel, Switzerland)2022

Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases.

Vincenzo Algieri, Paola Costanzo, Matteo Antonio Tallarida, Fabrizio Olivito, Antonio Jiritano, Giulia Fiorani, Francesca Peccati, Gonzalo Jiménez-Osés, Loredana Maiuolo, Antonio De Nino

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vincenzo AlgieriDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-1163-8072
Paola CostanzoDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-2205-1541
Matteo Antonio TallaridaDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-9590-2861
Fabrizio OlivitoDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0001-8989-1126
Antonio JiritanoDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0001-7432-6466
Giulia FioraniDepartment Molecular Sciences and Nanosystems, University Ca' Foscari Venezia, 30172 Mestre (VE), Italy.ORCID 0000-0003-1370-2952
Francesca PeccatiCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160 Derio, Spain.
Gonzalo Jiménez-OsésCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160 Derio, Spain.ORCID 0000-0003-0105-4337
Loredana MaiuoloDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-8936-4454
Antonio De NinoDepartment of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-9513-5199
University of Calabria · ITCIC bioGUNE · ESCa' Foscari University of Venice · ITIkerbasque · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,2,3-triazoles are versatile building blocks with growing interest in medicinal chemistry. For this reason, organic chemistry focuses on the development of new synthetic pathways to obtain 1,2,3-triazole derivatives, especially with pyridine moieties. In this work, a novel series of 1,5-disubstituted-1,2,3-triazoles functionalized with pyrimidine nucleobases were prepared via 1,3-dipolar cycloaddition reaction in a regioselective manner for the first time. The

Indexed as

COVID-19SARS-CoV-2AzidesHumansMolecular Docking SimulationPyrimidinesTriazolesAzidespyrimidinePyrimidinesTriazoles1,2,3-triazolesADMEclick chemistryLewis acidmolecular dockingnucleobases

Identifiers

PMID36500573
PMCPMC9735522
OpenAlexW4311530093

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.