Evidence map›Paper›PMID 36503541›Full record

Observational studyBMC research notes2022

Impact of blood perilipin A levels on obesity and metabolic health.

Emmanuel K Ofori, Bright Selorm Letsu, Seth K Amponsah, John Ahenkorah, Sandra Crabbe, Genevieve Kwao-Zigah, Sylvester Y Oppong, Patrick Diaba-Nuhoho, Seth D Amanquah

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Emmanuel K OforiDepartment of Chemical Pathology, University of Ghana Medical School, Accra, Ghana. ekofori1@ug.edu.gh.ORCID http://orcid.org/0000-0001-7375-8830
Bright Selorm LetsuDepartment of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.
Seth K AmponsahDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.
John AhenkorahDepartment of Anatomy, University of Ghana Medical School, Accra, Ghana.
Sandra CrabbeKorle-Bu Teaching Hospital, Accra, Ghana.
Genevieve Kwao-ZigahDepartment of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.
Sylvester Y OppongInternational Maritime Hospital, Tema, Ghana.
Patrick Diaba-NuhohoDepartment of Medicine III, University of Technology, Dresden, Germany.
Seth D AmanquahDepartment of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.
University of Ghana · GHKorle Bu Teaching Hospital · GHTechnische Universität Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePerilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health.

resultsThe participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = - 0.32, - 0.37, - 0.40, - 0.45, - 0.33 and - 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35-11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.

Indexed as

Insulin ResistanceAdultBody Mass IndexCross-Sectional StudiesHumansMiddle AgedObesityPerilipin-1Perilipin-1Insulin resistanceLipidsObesityPerilipin A

Identifiers

PMID36503541
PMCPMC9743615
OpenAlexW4311125291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.