Evidence map›Paper›PMID 36504065›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Expression of miR-342-3p in rheumatoid arthritis patients and its effect on synovial fibroblast inflammation and migration].

Q Zhou, J Liu, Y Sun, X Chen, X Zhang, X Ding

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Q ZhouFirst Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230012, China.
J LiuFirst Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230012, China.
Y SunFirst Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230012, China.
X ChenFirst Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230012, China.
X ZhangFirst Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230012, China.
X DingFirst Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression level of miR-342-3p in peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA) and its effect on inflammatory response and migration of synovial fibroblasts in RA (RA-FLS).

methodsPBMCs were collected from 30 healthy individuals and 50 RA patients for detecting the expression of miR-342-3p, and its correlation with the clinical indicators RF, ESR, anti-CCP, hs-CRP, C3, DAS-28, SAS, and SDS was analyzed. In RA-FLS cultures, the effect of transfection of miR-342-3p mimics and inhibitor on TNF-

resultsIn RA patients, the expression level of miR-342-3p was significantly lowered in the PBMCs (

conclusionThe expression of miR-342-3p is decreased in the PBMCs of RA patients. A lowered expression of miR-342-3p contributes to the pathogenesis of RA by promoting inflammatory responses and migration of RA-FLS.

Indexed as

Arthritis, RheumatoidMicroRNAsAnti-Citrullinated Protein AntibodiesC-Reactive ProteinFibroblastsHumansInflammationInterleukin-10Interleukin-6Leukocytes, MononuclearTumor Necrosis Factor-alphaAnti-Citrullinated Protein AntibodiesC-Reactive ProteinInterleukin-10Interleukin-6MicroRNAsMIRN342 microRNA, humanTumor Necrosis Factor-alphainflammationmigrationmiR-342-3prheumatoid arthritis

Identifiers

PMID36504065
PMCPMC9742770

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.