Evidence map›Paper›PMID 36505397›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Factors influencing the participation of Black and White Americans in Alzheimer's disease biomarker research.

Johanne Eliacin, Elizabeth Hathaway, Sophia Wang, Caitlin O'Connor, Andrew J Saykin, Kenzie A Cameron

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Return of research results across the Alzheimer's Disease Research Centers network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Understanding Inclusion and Participation of People From Black African Diaspora Communities in Health and Care Research: A Realist Review.Health expectations : an international journal of public participation in health care and health policy · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Post-disclosure distress among racial and ethnic groups in a preclinical AD trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Johanne EliacinVA HSR&D Center for Health Information and Communication Richard L. Roudebush VA Medical Center Indianapolis Indiana USA.
Elizabeth HathawayDepartment of Psychiatry Indiana University School of Medicine Indianapolis Indiana USA.
Sophia WangIndiana Alzheimer's Disease Research Center Indiana University School of Medicine Indianapolis Indiana USA.
Caitlin O'ConnorVA HSR&D Center for Health Information and Communication Richard L. Roudebush VA Medical Center Indianapolis Indiana USA.
Andrew J SaykinIndiana Alzheimer's Disease Research Center Indiana University School of Medicine Indianapolis Indiana USA.
Kenzie A CameronDepartment of Medicine Division of General Internal Medicine Feinberg School of Medicine Northwestern University Chicago Illinois USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineNorthwestern University · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
The Role of ICU Delirium and Vascular Risk Factors in the Development of Post-ICU Cognitive Impairment and DementiaK23AG062555 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI WANG, SOPHIA · 2019 to 2023
$808k
NIA NIH HHS K23 AG062555NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771
6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD) is a public health priority. AD biomarkers may vary based on race, but the recruitment of diverse participants has been challenging. Methods: Three groups of Black and White participants with and without prior research advocacy or participation were interviewed individually or in focus groups to better understand perspectives related to AD biomarker research participation. A rapid qualitative data analytic approach was used to analyze the data. Results: Identified barriers to AD biomarker research participation included hesitancy due to fear, distrust of research and researchers, lack of relevant knowledge, and lack of research test results disclosure. Drivers for engagement in biomarker research procedures included knowledge about research, AD, and related clinical procedures, perceived benefits of participation, and outreach from trusted sources. Discussion: Participants' comments related to the need for diversity in research and desire for results disclosure suggest opportunities to engage Black individuals. Highlights: Black Americans experience more salient barriers to Alzheimer's disease (AD) biomarker research participation.Concerns about research diversity influence research participation decisions.Research test disclosure may affect research participation and retention.

Indexed as

AD biomarkerhealth disparityqualitative research methodsracial diversityresearch participation

Identifiers

PMID36505397
PMCPMC9728547
OpenAlexW4311289338

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.