Evidence map›Paper›PMID 36506595›Full record

ArticleComputational and mathematical methods in medicine2022

Exploring the Mechanism of Action of

Lingmiao Wen, Yuqing Fan, Wei Xiong, Yanjun Liu, Tinglan Zhang, Guihua Wei, Alvin Altamirano, Tian-E Zhang, Zhiyong Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lingmiao WenSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0002-6574-1104
Yuqing FanSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0002-0522-7090
Wei XiongSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0002-6769-5244
Yanjun LiuSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0002-0109-8973
Tinglan ZhangSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0002-0375-2342
Guihua WeiSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0002-8736-8902
Alvin AltamiranoDepartment of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ, USA.ORCID https://orcid.org/0000-0002-7346-3597
Tian-E ZhangSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0000-0002-1081-5532
Zhiyong YanSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.ORCID https://orcid.org/0000-0003-3596-9463

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To reveal the safety, efficacy, and mechanism of action of Methods: The maximum dose method was employed to evaluate the safety of TCEF, and its antidepressant activity was assessed using the tail suspension and sugar water depletion tests. The main components of TCEF were determined using ultrahigh performance liquid chromatography coupled with quadrupole exactive orbitrap mass spectrometer (UHPLC-Q-EOMS). The active ingredients and their action targets were obtained using network pharmacology with SwissADME and SwissTargetPrediction screening, and the targets of depression were obtained using GeneCards, DrugBank, etc. The drug and depression-related targets were intersected and analyzed Results: No statistically significant difference was observed between the normal and TCEF groups in terms of body weight, visceral index, and biochemical parameters ( Conclusions: TCEF is a relatively safe antidepressant medicine that exerts therapeutic effects through multiple components, targets, and pathways, providing a new idea and theoretical basis for future use of TCEF to treat depression.

Indexed as

Drugs, Chinese HerbalNetwork PharmacologyBody WeightComputer SimulationHumansMedicine, Chinese TraditionalMolecular Docking SimulationSugarsDrugs, Chinese HerbalSugars

Identifiers

PMID36506595
PMCPMC9729047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.