Evidence map›Paper›PMID 36509749›Full record

ArticleNature communications2022

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.

Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. The Sirtuin Network: Linking NADDiabetes/metabolism research and reviews · 2026
    Review
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  5. NBiomolecules · 2026
    Review
  6. Article
  7. Article
  8. Sirtuins Contribute to the Migraine-Stroke Connection.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 4 countries.

Tatsuya YoshizawaDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan. yoshizaw@kumamoto-u.ac.jp.ORCID 0000-0002-5728-1996
Yoshifumi SatoDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.ORCID 0000-0003-0697-1476
Shihab U SobuzDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Tomoya MizumotoDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Tomonori TsuyamaCenter for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Md Fazlul KarimDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Keishi MiyataDepartment of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Masayoshi TasakiDepartment of Neurology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Masaya YamazakiDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.ORCID 0000-0003-4151-4983
Yuichi KaribaDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Norie ArakiDepartment of Tumor Genetics and Biology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Eiichi ArakiCenter for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Shingo KajimuraBeth Israel Deaconess Medical Center, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, 02215, USA.ORCID 0000-0003-0672-5910
Yuichi OikeCenter for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.ORCID 0000-0003-3245-5395
Thomas BraunDepartment of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Ludwigstr. 43, 61231, Bad Nauheim, Germany.ORCID 0000-0002-6165-4804
Eva BoberDepartment of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Ludwigstr. 43, 61231, Bad Nauheim, Germany.
Johan AuwerxLaboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5065-5393
Kazuya YamagataDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan. k-yamaga@kumamoto-u.ac.jp.
Kumamoto University · JPMax Planck Institute for Heart and Lung Research · DEBeth Israel Deaconess Medical Center · USÉcole Polytechnique Fédérale de Lausanne · CHKumamoto Health Science University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brown adipose tissue plays a central role in the regulation of the energy balance by expending energy to produce heat. NAD

Indexed as

Adipose Tissue, BrownSirtuinsAnimalsEnergy MetabolismMammalsMiceMice, KnockoutRNA, MessengerThermogenesisUncoupling Protein 1RNA, MessengerSirt7 protein, mouseSirtuinsUncoupling Protein 1

Identifiers

PMID36509749
PMCPMC9744749
OpenAlexW4311156471

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.