ArticleCell reports. Medicine2022
Correlations between complex human phenotypes vary by genetic background, gender, and environment.
Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies.PLoS genetics · 2026Article
- Computationally efficient methods for estimating phenome-wide coheritability of multi-type phenotypes using biobank data.Communications biology · 2025Article
- ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets.Communications biology · 2025Article
- Leveraging Alzheimer's Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma.Molecular neurobiology · 2025Article
- A one-shot, lossless algorithm for cross-cohort learning in mixed-outcomes analysis.Patterns (New York, N.Y.) · 2025Article
- Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases.Nature communications · 2025Article
- Article
- PCOS - the many faces of a disorder in women and men.Journal of endocrinological investigation · 2025Review
- Tradeoffs in Modeling Context Dependency in Complex Trait Genetics.bioRxiv : the preprint server for biology · 2025Article
- The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank.Human genomics · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males.Frontiers in psychiatry · 2025Article
- A population-based study of familial coaggregation and shared genetic etiology of psychiatric and gastrointestinal disorders.Communications medicine · 2024Article
- Review
- Estimation of Genetic Correlation Between Rheumatoid Arthritis and Multiple Sclerosis Using Summary Statistics from Genome-Wide Association Studies.Journal of clinical practice and research · 2023Article
- The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?International journal of environmental research and public health · 2023Review
Corrections and comments
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Authors and funding
23 authors at 14 institutions in 1 country.
Funding
Abstract
We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both heritabilities and genetic correlations for multiple phenotypes and phenotype pairs between individuals of self-reported Black, Hispanic/Latino, and White backgrounds. We similarly observe differences in many of the genetic and environmental correlations between genders. To estimate the contribution of genetics to the observed phenotypic correlation, we introduce "fractional genetic correlation" as the fraction of phenotypic correlation explained by genetics. Finally, we quantify the enrichment of correlations between phenotypic domains, each of which is comprised of multiple phenotypes. Altogether, we demonstrate that the observed correlations between complex human phenotypes depend on the genetic background of the individuals, their gender, and their environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.