ArticleScientific reports2022
External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cooling devices used to avoid warm ischemia time injury during kidney transplantation. Systematic review and meta-analysis.Frontiers in medical technology · 2025Pooled it
- Islet dimension and its impact on transplant outcome: A systematic review.World journal of transplantation · 2025Article
- Densely vascularized thick 3D tissue shows enhanced protein secretion constructed with intermittent positive pressure.Communications biology · 2025Article
- The establishment of anJournal of thoracic disease · 2024Article
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Authors and funding
6 authors.
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Abstract
Normothermic machine perfusion (NMP) has not yet been established as a technique for preserving organs for a day. A key contributing factor to the same is that the perfusing solutions cannot circulate continuously and evenly in the organs. Here, we conceived a method of applying intermittent air pressure from outside the organ to assist its circulatory distribution during perfusion. We used a perfusion culture system while applying external pressure to culture rat kidneys and compared the circulatory distribution in the kidneys, changes in tissue morphology due to injury, and perfusate filtration. The intermittent pressurization (IMP) (-) group showed markedly poorer circulation on the upper side compared with that in the lower side, alongside histological damage. On the other hand, the IMP (+) group showed improved circulation in the upper side and had lesser histological damage. Furthermore, the IMP (+) group maintained the ability to filter perfusate for 24 h. In transplantation medicine and regenerative medicine research, this method has the potential to contribute to more efficient organ preservation and more functional tissue regeneration in the future.
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