Evidence map›Paper›PMID 36525124›Full record

ArticleNeurochemical research2023

The Agonist of Adenosine A1 Receptor Induced Desensitization of delta Opioid receptor-mediated Raf-1/MEK/ERK Signaling by Feedback Phosphorylation of Raf-1-Ser289/296/301.

Chi Xu, Yun Cheng, Manman Han, Yimin Tao, Jing-Gen Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Chi XuDepartment of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Affiliated Hospital of Zhejiang Chinese Medical University, 310053, Hangzhou, China. xuchi@zcmu.edu.cn.
Yun ChengKey Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Manman HanSchool of Pharmacy, Zhejiang Chinese Medical University, 310053, Hangzhou, China.
Yimin TaoKey Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Jing-Gen LiuDepartment of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Affiliated Hospital of Zhejiang Chinese Medical University, 310053, Hangzhou, China. jgliu@simm.ac.cn.
Zhejiang Chinese Medical University · CNChinese Academy of Sciences · CNShanghai Institute of Materia Medica · CNThe Third Affiliated Hospital of Zhejiang Chinese Medical University · CN

Funding

National Natural Science Foundation of China 82030112Natural Science Foundation of Zhejiang Province LY22H270004Zhejiang Chinese Medical University 2020ZG53
6 · The paper itself

Abstract

Our previous study found that activation of adenosine A1 receptor (A

Indexed as

Receptor, Adenosine A1Receptors, Opioid, deltaAnalgesics, OpioidFeedbackMAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesPhosphorylationSignal TransductionAnalgesics, OpioidMitogen-Activated Protein Kinase KinasesReceptor, Adenosine A1Receptors, Opioid, deltaAdenosine A1 receptorDelta opioid receptorDesensitizationN6-cyclohexyladenosineRaf-1

Identifiers

PMID36525124
OpenAlexW4311671303

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.