Evidence map›Paper›PMID 36537793›Full record

ArticleMicrobiology spectrum2023

Avian Metapneumovirus Subgroup C Phosphoprotein Suppresses Type I Interferon Production by Blocking Interferon Regulatory Factor 3 Nuclear Translocation.

Lei Hou, Yongyan Shi, Jinshuo Guo, Tong Sun, Dedong Wang, Xiaoyu Yang, Changzhe Liu, Yongqiu Cui, Ning Zhu, Xinxin Tong and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lei HouCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Yongyan ShiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Jinshuo GuoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Tong SunCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Dedong WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Xiaoyu YangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Changzhe LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Yongqiu CuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Ning ZhuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Xinxin TongCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Yang PanCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Xufei FengCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Jianwei ZhouCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Jue LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.ORCID 0000-0001-7457-7492
Yangzhou University · CNAnhui Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Avian metapneumovirus subgroup C (aMPV/C) is an important pathogen that causes upper respiratory symptoms and egg production decline in turkeys and chickens. aMPV/C infection leads to inhibition of the host antiviral immune response. However, our understanding of the molecular mechanisms underlying host immune response antagonized by aMPV/C infection is limited. In this study, we demonstrated that the aMPV/C phosphoprotein (P) inhibits the IFN antiviral signaling pathway triggered by melanoma differentiation gene 5 (MDA5) and reduces interferon β (IFN-β) production and IFN-stimulated genes (ISGs) by targeting IFN regulatory factor 7 (IRF7) but not nuclear factor κB (NF-κB) in DF-1 cells. Moreover, we found that aMPV/C P protein only blocks the nuclear translocation of IRF3 by interacting with IRF3 in HEK-293T cells, instead of affecting IRF3 phosphorylation and inducing IRF3 degradation, which suppresses IRF3 signaling activation and results in a decrease in IFN-β production. Collectively, these results reveal a novel mechanism by which aMPV/C infection disrupts IFN-β production in the host.

Indexed as

Interferon Regulatory Factor-3Interferon Type IMetapneumovirusPhosphoproteinsAnimalsChickensHost-Pathogen InteractionsInterferon-betaViral ProteinsInterferon-betaInterferon Regulatory Factor-3Interferon Type IPhosphoproteinsViral Proteinsavian metapneumovirus subgroup CIFN-β productionIRF3nuclear translocationphosphoprotein

Identifiers

PMID36537793
PMCPMC9927154
OpenAlexW4312019031

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.