ArticleEndocrine2023
Correlation between thyroid function, sensitivity to thyroid hormones and metabolic dysfunction-associated fatty liver disease in euthyroid subjects with newly diagnosed type 2 diabetes.
Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association between thyroid function and metabolic associated fatty liver disease: a systemic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Seasonal fluctuations in the hypothalamic irisin and its correlation with the hypothalamic-pituitary-gonadal -axis activity in male rhesus monkeys (Macaca mulatta).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Review
- Aescin and rutin mitigate hyperthyroidism-induced multisystem dysfunction via antioxidant and anti-inflammatory mechanisms in a rat model.Scientific reports · 2026Article
- Association Between Thyroid Function Indicators and Metabolic-Associated Fatty Liver Disease: Effect Modification by Iodine Nutritional Status.International journal of endocrinology · 2026Article
- Association Between Thyroid Hormone Sensitivity Indicators and Controlled Attenuation Parameter (CAP) Values in Euthyroid Adults with Overweight/Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Impact of thyroid dysfunction and diabetes on fibrosis and steatosis stages in metabolic dysfunction associated fatty liver disease.Scientific reports · 2025Article
- Thyroid Hormone Sensitivity as a Possible Determinant of Metabolic Phenotypes in Young Adults, Not in Older Individuals.The Journal of clinical endocrinology and metabolism · 2025Article
- Impaired central thyroid hormone sensitivity is associated with time in range in patients with type 2 diabetes mellitus in the euthyroid population.Diabetology & metabolic syndrome · 2025Article
- The Correlation Between Impaired Thyroid Hormone Sensitivity and Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of Sensitivity to Thyroid Hormones and Non-Alcoholic Fatty Liver Disease and the Severity of Liver Fibrosis in Euthyroid Adults: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Pituitary-Thyroid Hormones and Related Indices in Euthyroid Type 2 Diabetes: Association With Thyroid Nodules.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study.Frontiers in genetics · 2025Article
- Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population.Frontiers in endocrinology · 2025Article
- Impaired sensitivity to thyroid hormones is associated with ASCVD risk factors in Beijing in euthyroid population: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Association Between Thyroid Hormone Sensitivity and Non-Alcoholic Fatty Liver Disease in Individuals with Normal Thyroid Function.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Impaired thyroid hormone sensitivity is associated with the degrees of fatty infiltration in metabolic dysfunction associated steatotic liver disease.Frontiers in endocrinology · 2025Article
- Expressions of glycemic parameters, lipid profile, and thyroid hormone in patients with type 2 diabetes mellitus and their correlation.Immunity, inflammation and disease · 2024Article
- Relationship between Thyroid Feedback Quantile-based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007-2012.Clinical cardiology · 2024Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo estimate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and to evaluate the associations between thyroid parameters, MAFLD and liver fibrosis in euthyroid patients with newly diagnosed type 2 diabetes mellitus (T2DM).
methodsOverall, 776 patients with newly diagnosed T2DM and 120 subjects without diabetes were included. All the participants were euthyroid, and were categorized as non-MAFLD and MAFLD. Demographic information, biochemical parameters, and serum thyroid hormones were collected. The thyroid hormone sensitivity indices were calculated. MAFLD was defined according to abdominal ultrasound and clinical manifestations. Noninvasive fibrosis indices were calculated to identify advanced liver fibrosis.
resultsThe prevalence of MAFLD was significantly higher in patients with T2DM than in subjects without diabetes. Levels of free triiodothyronine (FT3) and FT3 to free thyroxine (FT4) ratio were significantly higher in subjects with MAFLD. In patients with T2DM, levels of thyroid stimulating hormone (TSH), Thyroid feedback quantile-based index (TFQI
conclusionMAFLD was prevalent in euthyroid patients with newly diagnosed T2DM. Higher normal FT3, TSH and impaired sensitivity to thyroid hormones are associated with increased incidence of MAFLD, being dependent on other metabolic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.