ArticleScientific reports2022
Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Glutamatergic projection neurons in the basal forebrain underlie learned olfactory associational valence assignments.Nature communications · 2026Article
- Alteration of gut microbial ecology by the direct activation of the brain: Inverse gut-microbiome-brain dynamics.iScience · 2025Article
- Basal Forebrain to Ventral Tegmental Area Glutamatergic Pathway Promotes Emergence from Isoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Refining the role of the paraventricular hypothalamus in feeding behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Glutamatergic lateral habenula neurons modulate consolidation of associative memories.Frontiers in behavioral neuroscience · 2025Article
- Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice.Nature metabolism · 2024Article
- Cholinergic Basal Forebrain Connectivity to the Basolateral Amygdala Modulates Food Intake.eNeuro · 2024Article
- Article
- Neuronal activation in the paraventricular thalamus and lateral habenula during activity-based anorexia in mice.Neuroscience applied · 2024Article
- Optogenetics Neuromodulation of the Nose.Behavioural neurology · 2024Review
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many of the neural circuits that drive more complex, non-homeostatic feeding that integrate valence and sensory cues (such as taste and smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit that directly modulates non-homeostatic feeding behavior. Using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the BF that project to the LHb, which responds to diverse sensory cues, including aversive and food-related odors. Optogenetic activation of BF-to-LHb circuitry drives robust, reflexive-like aversion. Furthermore, activation of this circuitry suppresses the drive to eat in a fasted state. Together, these data reveal a role of basal forebrain glutamatergic neurons in modulating LHb-associated aversion and feeding behaviors by sensing environmental cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.